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Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase) Mus musculus
Symbol: Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Description: Predicted to have several functions, including GTPase activity; anion binding activity; and microtubule binding activity. Involved in mitochondrial fusion; negative regulation of apoptotic signaling pathway; and neural tube closure. Localizes to the dendrite; mitochondrial inner membrane; and mitochondrial intermembrane space. Used to study optic atrophy. Human ortholog(s) of this gene implicated in dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; and optic atrophy. Is expressed in several structures, including heart; liver; lung; skin; and visual system. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200011N24Rik; AI225888; AI847218; dynamin-like 120 kDa protein, mitochondrial; large GTP-binding protein; largeG; lilr3; mKIAA0567; optic atrophy 1; optic atrophy 1 homolog; optic atrophy protein 1 homolog
Homo sapiens (human) : OPA1 (OPA1 mitochondrial dynamin like GTPase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Opa1 (OPA1, mitochondrial dynamin like GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Canis lupus familiaris (dog) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Sus scrofa (pig) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Chlorocebus sabaeus (green monkey) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Heterocephalus glaber (naked mole-rat) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1629,579,334 - 29,654,884 (+)Ensembl
GRCm381629,579,281 - 29,663,127 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371629,579,428 - 29,652,576 (+)NCBIGRCm37mm9NCBIm37
MGSCv361629,499,089 - 29,572,237 (+)NCBImm8
Celera1630,084,438 - 30,158,233 (+)NCBICelera
Cytogenetic Map16 B2NCBI
cM Map1620.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Opa1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551416
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.