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Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase) Mus musculus
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Symbol: Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Description: Predicted to have several functions, including GTPase activity; anion binding activity; and microtubule binding activity. Involved in mitochondrial fusion; negative regulation of apoptotic signaling pathway; and neural tube closure. Localizes to the dendrite; mitochondrial inner membrane; and mitochondrial intermembrane space. Used to study optic atrophy. Human ortholog(s) of this gene implicated in dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; and optic atrophy. Is expressed in several structures, including heart; liver; lung; skin; and visual system. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200011N24Rik; AI225888; AI847218; dynamin-like 120 kDa protein, mitochondrial; large GTP-binding protein; largeG; lilr3; mKIAA0567; optic atrophy 1; optic atrophy 1 homolog; optic atrophy protein 1 homolog
Orthologs:
Homo sapiens (human) : OPA1 (OPA1 mitochondrial dynamin like GTPase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Opa1 (OPA1, mitochondrial dynamin like GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Canis lupus familiaris (dog) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Sus scrofa (pig) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Chlorocebus sabaeus (green monkey) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Heterocephalus glaber (naked mole-rat) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1629,579,334 - 29,654,884 (+)Ensembl
GRCm381629,579,281 - 29,663,127 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371629,579,428 - 29,652,576 (+)NCBIGRCm37mm9NCBIm37
MGSCv361629,499,089 - 29,572,237 (+)NCBImm8
Celera1630,084,438 - 30,158,233 (+)NCBICelera
Cytogenetic Map16 B2NCBI
cM Map1620.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Opa1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551416
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.