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Gene: H2-DMa (histocompatibility 2, class II, locus DMa) Mus musculus
Symbol: H2-DMa
Name: histocompatibility 2, class II, locus DMa
CRRD ID: 1551725
Description: Predicted to have MHC class II protein complex binding activity. Involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; chaperone cofactor-dependent protein refolding; and positive regulation of immune response. Localizes to endosome membrane; lysosomal membrane; and multivesicular body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human HLA-DMA (major histocompatibility complex, class II, DM alpha); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: class II histocompatibility antigen, M alpha chain; H-2M; H-2Ma; H2-M; H2-M alpha; H2-Ma; histocompatibility 2, class II, locus Ma; MHC class II antigen DMa
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,338,667 - 34,358,075 (+)NCBI
GRCm381734,119,693 - 34,139,101 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,119,541 - 34,139,101 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,272,616 - 34,275,480 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,746,082 - 33,749,555 (+)NCBImm8
Celera1736,887,536 - 36,890,397 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-DMa
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551725
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.