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Gene: H2-Oa (histocompatibility 2, O region alpha locus) Mus musculus
Symbol: H2-Oa
Name: histocompatibility 2, O region alpha locus
CRRD ID: 1551754
Description: Predicted to have MHC class II protein complex binding activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and regulation of T cell differentiation. Predicted to localize to MHC class II protein complex. Is expressed in several structures, including central nervous system; cornea; genitourinary system; palatal shelf; and salivary gland. Orthologous to human HLA-DOA (major histocompatibility complex, class II, DO alpha); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H-2; H-2Oa; MHC class II antigen O region alpha locus
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,311,353 - 34,314,286 (+)NCBI
GRCm381734,092,379 - 34,095,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,092,340 - 34,095,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,229,324 - 34,232,179 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,702,886 - 33,705,688 (+)NCBImm8
Celera1736,839,367 - 36,842,221 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-Oa
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551754
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.