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Gene: Crb2 (crumbs family member 2) Mus musculus
Symbol: Crb2
Name: crumbs family member 2
Description: Predicted to have aspartic-type endopeptidase inhibitor activity. Involved in several processes, including embryonic morphogenesis; maintenance of epithelial cell apical/basal polarity; and positive regulation of BMP signaling pathway. Localizes to the apical plasma membrane. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9. Is expressed in early conceptus and embryo. Orthologous to human CRB2 (crumbs cell polarity complex component 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; Benzo[ghi]perylene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5930402A21; BC043114; crumbs homolog 2; crumbs-like protein 2; crumbs2
Homo sapiens (human) : CRB2 (crumbs cell polarity complex component 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Crb2 (crumbs cell polarity complex component 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crb2 (crumbs cell polarity complex component 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CRB2 (crumbs cell polarity complex component 2)
Canis lupus familiaris (dog) : CRB2 (crumbs cell polarity complex component 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crb2 (crumbs cell polarity complex component 2)
Sus scrofa (pig) : CRB2 (crumbs cell polarity complex component 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl237,776,249 - 37,799,103 (+)Ensembl
GRCm38237,776,225 - 37,799,103 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37237,631,769 - 37,654,623 (+)NCBIGRCm37mm9NCBIm37
Celera237,461,524 - 37,484,418 (+)NCBICelera
Cytogenetic Map2 BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Crb2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1551852
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.