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Gene: Lemd2 (LEM domain containing 2) Mus musculus
Symbol: Lemd2
Name: LEM domain containing 2
CRRD ID: 1552183
Description: Predicted to have chromatin DNA binding activity. Involved in several processes, including heart formation; negative regulation of intracellular signal transduction; and skeletal muscle cell differentiation. Localizes to nuclear membrane. Predicted to colocalize with chromatin; endoplasmic reticulum; and nuclear envelope. Is expressed in several structures, including heart; liver; nephric duct; neural tube; and tibialis anterior. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC026588; Lem; LEM domain-containing protein 2; Lem2; MGC37253; NET2; NET25; nuclear envelope constituent; nuclear envelope transmembrane protein 25
Homo sapiens (human) : LEMD2 (LEM domain nuclear envelope protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lemd2 (LEM domain nuclear envelope protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lemd2 (LEM domain nuclear envelope protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LEMD2 (LEM domain nuclear envelope protein 2)
Canis lupus familiaris (dog) : LEMD2 (LEM domain nuclear envelope protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lemd2 (LEM domain nuclear envelope protein 2)
Sus scrofa (pig) : LEMD2 (LEM domain nuclear envelope protein 2)
Chlorocebus sabaeus (African green monkey) : LEMD2 (LEM domain nuclear envelope protein 2)
Heterocephalus glaber (naked mole-rat) : Lemd2 (LEM domain nuclear envelope protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391727,408,574 - 27,426,228 (-)NCBI
GRCm381727,189,600 - 27,205,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,189,600 - 27,204,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,326,545 - 27,341,383 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,917,346 - 26,931,337 (-)NCBImm8
Celera1727,725,463 - 27,740,360 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lemd2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552183
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.