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Gene: Lemd2 (LEM domain containing 2) Mus musculus
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Symbol: Lemd2
Name: LEM domain containing 2
CRRD ID: 1552183
Description: Predicted to have chromatin DNA binding activity. Involved in several processes, including heart formation; negative regulation of intracellular signal transduction; and skeletal muscle cell differentiation. Localizes to nuclear membrane. Predicted to colocalize with chromatin; endoplasmic reticulum; and nuclear envelope. Is expressed in several structures, including heart; liver; nephric duct; neural tube; and tibialis anterior. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC026588; Lem; LEM domain-containing protein 2; Lem2; MGC37253; NET2; NET25; nuclear envelope constituent; nuclear envelope transmembrane protein 25
Orthologs:
Homo sapiens (human) : LEMD2 (LEM domain nuclear envelope protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lemd2 (LEM domain nuclear envelope protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lemd2 (LEM domain nuclear envelope protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LEMD2 (LEM domain nuclear envelope protein 2)
Canis lupus familiaris (dog) : LEMD2 (LEM domain nuclear envelope protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lemd2 (LEM domain nuclear envelope protein 2)
Sus scrofa (pig) : LEMD2 (LEM domain nuclear envelope protein 2)
Chlorocebus sabaeus (African green monkey) : LEMD2 (LEM domain nuclear envelope protein 2)
Heterocephalus glaber (naked mole-rat) : Lemd2 (LEM domain nuclear envelope protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,408,574 - 27,426,228 (-)NCBI
GRCm381727,189,600 - 27,205,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,189,600 - 27,204,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,326,545 - 27,341,383 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,917,346 - 26,931,337 (-)NCBImm8
Celera1727,725,463 - 27,740,360 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lemd2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552183
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.