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Gene: Zeb1 (zinc finger E-box binding homeobox 1) Mus musculus
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Symbol: Zeb1
Name: zinc finger E-box binding homeobox 1
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in several processes, including embryonic organ morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Localizes to the nucleus. Used to study tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; embryo mesoderm; and genitourinary system. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3110032K11Rik; [delta]EF1; AREB6; BZP; delta EF1; MEB1; Nil2; TCF-8; Tcf18; Tcf8; transcription factor 8; Tw; twirler; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha; zinc finger E-box-binding homeobox 1; zinc finger homeobox 1a; zinc finger homeobox protein 1a
Orthologs:
Homo sapiens (human) : ZEB1 (zinc finger E-box binding homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Zeb1 (zinc finger E-box binding homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zeb1 (zinc finger E-box binding homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ZEB1 (zinc finger E-box binding homeobox 1)
Canis lupus familiaris (dog) : ZEB1 (zinc finger E-box binding homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zeb1 (zinc finger E-box binding homeobox 1)
Sus scrofa (pig) : ZEB1 (zinc finger E-box binding homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38185,591,327 - 5,775,468 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37185,591,889 - 5,774,909 (+)NCBIGRCm37mm9NCBIm37
MGSCv36185,591,889 - 5,774,909 (+)NCBImm8
Celera185,749,282 - 5,820,314 (+)NCBICelera
Cytogenetic Map18 A1NCBI
cM Map184.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Zeb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552190
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.