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Gene: Mmp13 (matrix metallopeptidase 13) Mus musculus
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Symbol: Mmp13
Name: matrix metallopeptidase 13
Description: This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Clg; collagenase 3; collagenase-1; Collagenase-3; interstitial collagenase; matrix metalloproteinase 13; matrix metalloproteinase-13; MMP-13; Mmp1
Orthologs:
Homo sapiens (human) : MMP13 (matrix metallopeptidase 13)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mmp13 (matrix metallopeptidase 13)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp13 (matrix metallopeptidase 13)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP13 (matrix metallopeptidase 13)
Canis lupus familiaris (dog) : MMP13 (matrix metallopeptidase 13)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp13 (matrix metallopeptidase 13)
Sus scrofa (pig) : MMP13 (matrix metallopeptidase 13)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3897,272,514 - 7,283,333 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3797,272,514 - 7,283,333 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,272,545 - 7,283,331 (+)NCBImm8
Celera94,675,357 - 4,686,177 (+)NCBICelera
Cytogenetic Map9 A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mmp13
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552243
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-05-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.