Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nefl (neurofilament, light polypeptide) Mus musculus
Symbol: Nefl
Name: neurofilament, light polypeptide
Description: Exhibits protein binding activity, bridging. Involved in several processes, including intermediate filament cytoskeleton organization; negative regulation of neuron apoptotic process; and nervous system development. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; cholinergic synapse; and intermediate filament cytoskeleton. Used to study Charcot-Marie-Tooth disease type 2E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Is expressed in several structures, including alimentary system; central nervous system; eye; limb; and peripheral nervous system ganglion. Orthologous to human NEFL (neurofilament light); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa neurofilament protein; AI847934; CMT2E; neurofilament light polypeptide; neurofilament protein L; neurofilament triplet L protein; NF-L; NF68; Nfl
Homo sapiens (human) : NEFL (neurofilament light)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nefl (neurofilament light)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefl (neurofilament light)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFL (neurofilament light)
Canis lupus familiaris (dog) : NEFL (neurofilament light)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefl (neurofilament light)
Sus scrofa (pig) : NEFL (neurofilament light)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1468,083,863 - 68,089,095 (+)Ensembl
GRCm381468,083,863 - 68,089,095 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371468,701,941 - 68,705,802 (+)NCBIGRCm37mm9NCBIm37
MGSCv361467,037,214 - 67,041,075 (+)NCBImm8
Celera1465,851,013 - 65,854,872 (+)NCBICelera
Cytogenetic Map14 D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nefl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552280
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.