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Gene: Nefl (neurofilament, light polypeptide) Mus musculus
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Symbol: Nefl
Name: neurofilament, light polypeptide
Description: Exhibits protein binding activity, bridging. Involved in several processes, including intermediate filament cytoskeleton organization; negative regulation of neuron apoptotic process; and nervous system development. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; cholinergic synapse; and intermediate filament cytoskeleton. Used to study Charcot-Marie-Tooth disease type 2E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Is expressed in several structures, including alimentary system; central nervous system; eye; limb; and peripheral nervous system ganglion. Orthologous to human NEFL (neurofilament light); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa neurofilament protein; AI847934; CMT2E; neurofilament light polypeptide; neurofilament protein L; neurofilament triplet L protein; NF-L; NF68; Nfl
Orthologs:
Homo sapiens (human) : NEFL (neurofilament light)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nefl (neurofilament light)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefl (neurofilament light)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFL (neurofilament light)
Canis lupus familiaris (dog) : NEFL (neurofilament light)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefl (neurofilament light)
Sus scrofa (pig) : NEFL (neurofilament light)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1468,083,863 - 68,089,095 (+)Ensembl
GRCm381468,083,863 - 68,089,095 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371468,701,941 - 68,705,802 (+)NCBIGRCm37mm9NCBIm37
MGSCv361467,037,214 - 67,041,075 (+)NCBImm8
Celera1465,851,013 - 65,854,872 (+)NCBICelera
Cytogenetic Map14 D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nefl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552280
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.