Gene: Ptprb (protein tyrosine phosphatase, receptor type, B) Mus musculus
Analyze
Symbol:
Ptprb
Name:
protein tyrosine phosphatase, receptor type, B
Description:
Predicted to have cadherin binding activity. Involved in angiogenesis and dephosphorylation. Predicted to localize to the receptor complex. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and liver. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
3230402H02Rik; C130094E24; protein-tyrosine phosphatase beta; Ptpz; R-PTP-beta; receptor-type tyrosine-protein phosphatase beta; Rptpb; vascular endothelial protein tyrosine phosphatase; VE-PTP; Veptp
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PTPRB (protein tyrosine phosphatase receptor type B) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Ptprb (protein tyrosine phosphatase, receptor type, B) HGNC
NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ptprb (protein tyrosine phosphatase receptor type B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PTPRB (protein tyrosine phosphatase receptor type B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PTPRB (protein tyrosine phosphatase receptor type B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ptprb (protein tyrosine phosphatase receptor type B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PTPRB (protein tyrosine phosphatase receptor type B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Ptprb (protein tyrosine phosphatase, receptor type, B)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Homo sapiens (human):
PTPRB (protein tyrosine phosphatase receptor type B)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
ptprb (protein tyrosine phosphatase, receptor type, b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
dep-1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Ptp10D
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Ptp4E
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 10 116,275,502 - 116,389,538 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 10 115,738,430 - 115,826,594 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 10 115,705,616 - 115,788,043 (+) NCBI mm8 Celera 10 118,242,005 - 118,330,326 (+) NCBI Celera Cytogenetic Map 10 D2 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
1,1-dichloroethene decreases expression EXP 6480464 vinylidene chloride results in decreased expression of PTPRB mRNA CTD PMID:26682919 1-nitropyrene increases expression ISO RGD:1314242 6480464 1-nitropyrene results in increased expression of PTPRB mRNA CTD PMID:19041380 17beta-estradiol multiple interactions ISO RGD:1314242 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of PTPRB mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PTPRB mRNA CTD PMID:19465110 , PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PTPRB mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1305922 6480464 Tetrachlorodibenzodioxin affects the expression of PTPRB mRNA CTD PMID:22298810 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of PTPRB mRNA CTD PMID:20188158 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of PTPRB mRNA CTD PMID:30951980 aflatoxin B1 decreases methylation ISO RGD:1314242 6480464 Aflatoxin B1 results in decreased methylation of PTPRB gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:1314242 6480464 Tretinoin results in increased expression of PTPRB mRNA CTD PMID:23724009 antirheumatic drug increases expression ISO RGD:1314242 6480464 Antirheumatic Agents results in increased expression of PTPRB mRNA CTD PMID:24449571 atrazine affects methylation ISO RGD:1305922 6480464 Atrazine affects the methylation of PTPRB gene CTD PMID:28931070 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of PTPRB mRNA CTD PMID:21569818 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA CTD PMID:27858113 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PTPRB mRNA CTD PMID:22228805 benzo[b]fluoranthene decreases expression EXP 6480464 benzo(b)fluoranthene results in decreased expression of PTPRB mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA CTD PMID:27858113 bisphenol F increases expression EXP 6480464 bisphenol F results in increased expression of PTPRB mRNA CTD PMID:30951980 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of PTPRB mRNA, Nanotubes, Carbon results in decreased expression of PTPRB mRNA CTD PMID:25554681 cefaloridine decreases expression ISO RGD:1305922 6480464 Cephaloridine results in decreased expression of PTPRB mRNA CTD PMID:18500788 chrysene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA CTD PMID:27858113 cisplatin increases expression ISO RGD:1314242 6480464 Cisplatin results in increased expression of PTPRB mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1314242 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of PTPRB mRNA CTD PMID:27392435 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of PTPRB mRNA CTD PMID:17585979 cocaine decreases expression ISO RGD:1314242 6480464 Cocaine results in decreased expression of PTPRB mRNA CTD PMID:18000554 copper atom multiple interactions ISO RGD:1314242 6480464 [NSC 689534 binds to Copper] which results in increased expression of PTPRB mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1314242 6480464 [NSC 689534 binds to Copper] which results in increased expression of PTPRB mRNA CTD PMID:20971185 dioxygen increases expression ISO RGD:1314242 6480464 Oxygen deficiency results in increased expression of PTPRB mRNA CTD PMID:24236059 , PMID:26516004 doxorubicin increases expression ISO RGD:1314242 6480464 Doxorubicin results in increased expression of PTPRB mRNA CTD PMID:30031762 ethanol multiple interactions ISO RGD:1314242 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of PTPRB mRNA CTD PMID:23378141 folic acid multiple interactions ISO RGD:1314242 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of PTPRB mRNA CTD PMID:23378141 iron(III) nitrilotriacetate decreases expression ISO RGD:1305922 6480464 ferric nitrilotriacetate results in decreased expression of PTPRB mRNA CTD PMID:10854235 isotretinoin increases expression ISO RGD:1314242 6480464 Isotretinoin results in increased expression of PTPRB mRNA CTD PMID:20436886 leflunomide increases expression ISO RGD:1314242 6480464 leflunomide results in increased expression of PTPRB mRNA CTD PMID:28988120 nefazodone decreases expression ISO RGD:1305922 6480464 nefazodone results in decreased expression of PTPRB mRNA CTD PMID:24136188 nickel atom decreases expression ISO RGD:1314242 6480464 Nickel results in decreased expression of PTPRB mRNA CTD PMID:25583101 nickel dichloride increases expression ISO RGD:1314242 6480464 nickel chloride results in increased expression of PTPRB mRNA CTD PMID:17312168 , PMID:21455298 nickel sulfate decreases expression ISO RGD:1314242 6480464 nickel sulfate results in decreased expression of PTPRB mRNA CTD PMID:22714537 nimesulide decreases expression ISO RGD:1305922 6480464 nimesulide results in decreased expression of PTPRB mRNA CTD PMID:24136188 phenobarbital multiple interactions EXP 6480464 NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PTPRB mRNA] CTD PMID:19482888 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of PTPRB mRNA CTD PMID:19482888 , PMID:23091169 silicon dioxide decreases expression ISO RGD:1314242 6480464 Silicon Dioxide analog results in decreased expression of PTPRB mRNA CTD PMID:25895662 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of PTPRB mRNA CTD PMID:23221170 sodium arsenate decreases expression EXP 6480464 sodium arsenate results in decreased expression of PTPRB mRNA CTD PMID:21795629 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of PTPRB mRNA CTD PMID:21795629 sodium arsenite decreases expression ISO RGD:1314242 6480464 sodium arsenite results in decreased expression of PTPRB mRNA CTD PMID:22714537 tetraphene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA CTD PMID:27858113 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of PTPRB mRNA CTD PMID:23557971 trichostatin A increases expression ISO RGD:1314242 6480464 trichostatin A results in increased expression of PTPRB mRNA CTD PMID:24935251 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of PTPRB mRNA CTD PMID:28973697 valproic acid decreases expression ISO RGD:1305922 6480464 Valproic Acid results in decreased expression of PTPRB mRNA CTD PMID:29427782 valproic acid affects splicing ISO RGD:1305922 6480464 Valproic Acid affects the splicing of PTPRB mRNA CTD PMID:29427782
Gene Ontology Annotations
Biological Process angiogenesis IMP 2290270 (MGI:MGI:3759922 more ... UniProtKB MGI:MGI:3759922 more ... angiogenesis IDA 2290270 (MGI:MGI:4412431, PMID:19451274) UniProtKB MGI:MGI:4412431 , PMID:19451274 dephosphorylation ISO UniProtKB:P23467 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 dephosphorylation IDA 2290270 (MGI:MGI:4412467 more ... UniProtKB MGI:MGI:4412467 more ... protein dephosphorylation IEA InterPro:IPR000242 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 Cellular Component integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 receptor complex ISO UniProtKB:P23467 2290270 (MGI:MGI:5474145, PMID:23382219) MGI MGI:MGI:5474145 , PMID:23382219 Molecular Function cadherin binding ISO UniProtKB:P23467 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 hydrolase activity IEA UniProtKB-KW:KW-0378 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 phosphatase activity IEA InterPro:IPR000387 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 phosphoprotein phosphatase activity IEA UniProtKB-KW:KW-0904 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI UniProtKB:Q02858 2290270 (MGI:MGI:4412467, PMID:10557082) UniProtKB MGI:MGI:4412467 , PMID:10557082 protein binding IPI UniProtKB:P55284 2290270 (MGI:MGI:4419091, PMID:12234928) UniProtKB MGI:MGI:4419091 , PMID:12234928 protein tyrosine phosphatase activity IEA EC:3.1.3.48 2290270 UniProtKB GO_REF:0000003, MGI:MGI:2152096 protein tyrosine phosphatase activity IEA InterPro:IPR000242 , InterPro:IPR016130 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098
Phenotype Annotations
1357740 Obsty3_m obesity 3 (mouse) Not determined 10 8359714 116355075 Mouse 1302067 Scc9_m colon tumor susceptibility 9 (mouse) Not determined 10 18383585 125739363 Mouse 13208560 Wght9_m weight 9 (mouse) 10 60000000 121000000 Mouse 11353832 Pcholq4_m plasma cholesterol QTL 4 (mouse) 10 74151384 125680038 Mouse 11353843 Gluq1_m blood glucose QTL 1 (mouse) 10 74151384 125680038 Mouse 1301165 Lith7_m lithogenic gene 7 (mouse) Not determined 10 82473556 116473795 Mouse 11059550 Lmr32a_m leishmaniasis resistance 32a (mouse) 10 82473556 116473795 Mouse 11059551 Lmr32b_m leishmaniasis resistance 32b (mouse) 10 82473556 116473795 Mouse 11059553 Lmr32d_m leishmaniasis resistance 32d (mouse) 10 82473556 116473795 Mouse 11059554 Lmr32e_m leishmaniasis resistance 32e (mouse) 10 82473556 116473795 Mouse 11059555 Lmr32f_m leishmaniasis resistance 32f (mouse) 10 82473556 116473795 Mouse 10043881 Adip24_m adiposity 24 (mouse) Not determined 10 82556941 116557090 Mouse 4141054 mwfh_m modifier of white forlock hypopigmentation (mouse) Not determined 83181141 117181274 Mouse 1357779 Tesq3_m testis weight QTL 3 (mouse) Not determined 10 84243786 122205623 Mouse 4141479 W10q8_m weight 10 weeks QTL 8 (mouse) Not determined 84243786 122205623 Mouse 4141387 Lgaq5_m late growth adjusted QTL 5 (mouse) Not determined 84243786 122205623 Mouse 4142496 W6q8_m weight 6 weeks QTL 8 (mouse) Not determined 84243786 122205623 Mouse 4142365 Egq9_m early growth QTL 9 (mouse) Not determined 84243786 122205623 Mouse 1357594 Estoq3_m embryo survival total QTL 3 (mouse) Not determined 10 84243786 122205623 Mouse 1357622 Espq3_m embryo survival preimplantation QTL 3 (mouse) Not determined 10 84243786 122205623 Mouse 1357638 Cia29_m collagen induced arthritis 29 (mouse) Not determined 10 85619118 118661448 Mouse 1300797 Sluc22_m susceptibility to lung cancer 22 (mouse) Not determined 10 86877747 120877895 Mouse 1301520 Uvbi1_m UVB induced immunosuppression 1 (mouse) Not determined 10 87073224 121073368 Mouse 1300908 Insq4_m insulin QTL 4 (mouse) Not determined 10 87073224 121073368 Mouse 1300921 Skl4_m skeletal size (tail length) 4 (mouse) Not determined 10 88252393 122252530 Mouse 4142386 Tgq20_m triglyceride QTL 20 (mouse) Not determined 89000595 123000595 Mouse 1301758 Fcsa3_m femoral cross-sectional area 3 (mouse) Not determined 10 90091790 124091893 Mouse 11039516 Ltpr5_m Leishmania tropica response 5 (mouse) 10 90671039 125739363 Mouse 13208554 Lgth11_m body length 11 (mouse) 10 91000000 121000000 Mouse 4142461 Bmd25_m bone mineral density 25 (mouse) Not determined 10 97381196 130694993 Mouse 1357544 Vtbt10_m vertebral trabecular bone trait 10 (mouse) Not determined 10 97381196 130694993 Mouse 11533919 Mvb4_m modifier of vibrator 4 (mouse) 3 97381196 130694993 Mouse 11533921 Mvb2_m modifier of vibrator 2 (mouse) 10 97381196 130694993 Mouse 12880413 V125Dq9_m vitamin D active form serum level QTL 9 (mouse) 10 97700000 130694993 Mouse 4141402 T2dm1sa_m type 2 diabetes mellitus 1 in SMXA RI mice (mouse) Not determined 97922739 130694993 Mouse 11040593 Lmr5e_m leishmaniasis resistance 5e (mouse) 10 99384730 130694993 Mouse 11040595 Lmr5c_m leishmaniasis resistance 5c (mouse) 10 99384730 130694993 Mouse 11040597 Lmr5a_m leishmaniasis resistance 5a (mouse) 10 99384730 130694993 Mouse 11059544 Lmr32_m leishmaniasis resistance 32 (mouse) 10 99473556 116384957 Mouse 11059552 Lmr32c_m leishmaniasis resistance 32c (mouse) 10 99473556 116384957 Mouse 1301968 Estq4_m estradiol regulated response QTL 4 (mouse) Not determined 10 101150611 130694993 Mouse 1357744 Cfbw4_m cystic fibrosis body weight 4 (mouse) Not determined 10 101150611 130694993 Mouse 1301901 Im5_m immunoregulatory 5 (mouse) Not determined 10 101661259 130694993 Mouse 4141361 Cfmq3_m cystic fibrosis modifier QTL 3 (mouse) Not determined 10 101661259 130694993 Mouse 1300678 Leg2_m longevity extending gene 2 (mouse) Not determined 10 102671003 130694993 Mouse 1301895 Exq1_m exploratory and excitability QTL 1 (mouse) Not determined 10 103011947 130694993 Mouse 14696727 Kidrq2_m kidney weight, right QTL 2 (mouse) 10 103066603 130694993 Mouse 4141007 Obrq10_m obesity resistance QTL 10 (mouse) Not determined 103407822 130694993 Mouse 4141487 Tgq21_m triglyceride QTL 21 (mouse) Not determined 104274116 130694993 Mouse 14746996 Manh69_m mandible shape 69 (mouse) 10 104927733 130694993 Mouse 1357482 Nhdlq4_m non-HDL QTL 4 (mouse) Not determined 10 105205399 130694993 Mouse 1300679 Nociq2_m nociceptive sensitivity inflammatory QTL 2 (mouse) Not determined 10 105205399 130694993 Mouse 1302200 Sle12_m systematic lupus erythematosus susceptibility 12 (mouse) Not determined 10 105205399 130694993 Mouse 4141269 Ipng2_m imprinted postnatal growth 2 (mouse) Not determined 105252393 118661448 Mouse 11040594 Lmr5f_m leishmaniasis resistance 5f (mouse) 10 105343808 130694993 Mouse 11040596 Lmr5d_m leishmaniasis resistance 5d (mouse) 10 105343808 130694993 Mouse 11040598 Lmr5b_m leishmaniasis resistance 5b (mouse) 10 105343808 130694993 Mouse 4142089 Obrq9_m obesity resistance QTL 9 (mouse) Not determined 108680038 130694993 Mouse 4141153 Ltgq2_m liver triglyceride QTL 2 (mouse) Not determined 108680038 130694993 Mouse 11039496 Ltpr5b_m Leishmania tropica response 5b (mouse) 10 108739225 130694993 Mouse 11041664 Lmr25_m leishmaniasis resistance 25 (mouse) 10 108739225 130694993 Mouse 11049563 Lmr25a_m leishmaniasis resistance 25a (mouse) 10 108739225 130694993 Mouse 11049570 Lmr25b_m leishmaniasis resistance 25b (mouse) 10 108739225 130694993 Mouse 11353822 Insq12_m insulin QTL 12 (mouse) 10 110617486 125680038 Mouse 11353823 Homaq2_m homeostatic model assessment QTL 2 (mouse) 10 110617486 125680038 Mouse 10412078 Hylaq3_m Hyperlocomotor activity related QTL 3 (mouse) Not determined 10 111732321 118150744 Mouse 4141242 Psrs2_m psoriasis susceptibility 2 (mouse) Not determined 10 114381196 118661448 Mouse 13506931 Recrq11_m recombination rate in male meiosis QTL 11 (mouse) 10 114500000 123800000 Mouse 1300796 Lmr5_m leishmaniasis resistance 5 (mouse) Not determined 10 116384730 122343923 Mouse
Predicted Target Of
Count of predictions: 1596 Count of miRNA genes: 752 Interacting mature miRNAs: 945 Transcripts: ENSMUST00000092167 Prediction methods: Miranda Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
