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Gene: Btrc (beta-transducin repeat containing protein) Mus musculus
Symbol: Btrc
Name: beta-transducin repeat containing protein
Description: Exhibits beta-catenin binding activity; protein phosphorylated amino acid binding activity; and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; mammary gland epithelium development; and regulation of signal transduction. Localizes to cytoplasm and nucleus. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; and liver. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase); PARTICIPATES IN Hedgehog signaling pathway; nuclear factor kappa B signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: b-TrCP; beta-transducin repeat-containing protein; beta-TrCP; beta-TrCP protein E3RS-IkappaB; Beta-Trcp1; E3RS-IkappaB; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; F-box/WD repeat-containing protein 1A; Fbw1a; FWD1; HOS; KIAA4123; mE3RS-IkappaB; mKIAA4123; pIkappaB-E3 receptor subunit; SCF b-TRCP; Slimb; ubiquitin ligase FWD1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1945,363,734 - 45,530,013 (+)EnsemblGRCm38mm10GRCm38
GRCm381945,363,688 - 45,533,343 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371945,438,224 - 45,607,833 (+)NCBIGRCm37mm9NCBIm37
MGSCv361945,409,208 - 45,583,324 (+)NCBImm8
Celera1946,131,196 - 46,300,930 (+)NCBICelera
Cytogenetic Map19C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Btrc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552424
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.