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Gene: Bbc3 (BCL2 binding component 3) Mus musculus
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Symbol: Bbc3
Name: BCL2 binding component 3
Description: Predicted to have ATPase binding activity. Involved in several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway; and positive regulation of apoptotic process. Predicted to colocalize with lysosome. Is expressed in several structures, including central nervous system; immune system; liver; retina; and skeletal muscle. Orthologous to human BBC3 (BCL2 binding component 3); PARTICIPATES IN intrinsic apoptotic pathway; Huntington's disease pathway; measles pathway; INTERACTS WITH (R)-lipoic acid; 1,1-dichloroethene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Bcl-2 binding component 3; bcl-2-binding component 3; BH3-only; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
Orthologs:
Homo sapiens (human) : BBC3 (BCL2 binding component 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bbc3 (Bcl-2 binding component 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bbc3 (BCL2 binding component 3)
Pan paniscus (bonobo/pygmy chimpanzee) : BBC3 (BCL2 binding component 3)
Canis lupus familiaris (dog) : BBC3 (BCL2 binding component 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bbc3 (BCL2 binding component 3)
Sus scrofa (pig) : BBC3 (BCL2 binding component 3)
Chlorocebus sabaeus (African green monkey) : BBC3 (BCL2 binding component 3)
Heterocephalus glaber (naked mole-rat) : Bbc3 (BCL2 binding component 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl716,308,393 - 16,318,205 (+)EnsemblGRCm38mm10GRCm38
GRCm38716,308,398 - 16,318,334 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37716,894,932 - 16,903,683 (+)NCBIGRCm37mm9NCBIm37
MGSCv36715,468,160 - 15,476,856 (+)NCBImm8
Celera713,504,637 - 13,513,389 (+)NCBICelera
Cytogenetic Map7A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Bbc3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552484
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.