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Gene: Bbc3 (BCL2 binding component 3) Mus musculus
Symbol: Bbc3
Name: BCL2 binding component 3
Description: Predicted to have ATPase binding activity. Involved in several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway; and positive regulation of apoptotic process. Predicted to colocalize with lysosome. Is expressed in several structures, including central nervous system; immune system; liver; retina; and skeletal muscle. Orthologous to human BBC3 (BCL2 binding component 3); PARTICIPATES IN intrinsic apoptotic pathway; Huntington's disease pathway; measles pathway; INTERACTS WITH (R)-lipoic acid; 1,1-dichloroethene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Bcl-2 binding component 3; bcl-2-binding component 3; BH3-only; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
Homo sapiens (human) : BBC3 (BCL2 binding component 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bbc3 (Bcl-2 binding component 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bbc3 (BCL2 binding component 3)
Pan paniscus (bonobo/pygmy chimpanzee) : BBC3 (BCL2 binding component 3)
Canis lupus familiaris (dog) : BBC3 (BCL2 binding component 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bbc3 (BCL2 binding component 3)
Sus scrofa (pig) : BBC3 (BCL2 binding component 3)
Chlorocebus sabaeus (African green monkey) : BBC3 (BCL2 binding component 3)
Heterocephalus glaber (naked mole-rat) : Bbc3 (BCL2 binding component 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl716,308,393 - 16,318,205 (+)EnsemblGRCm38mm10GRCm38
GRCm38716,308,398 - 16,318,334 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37716,894,932 - 16,903,683 (+)NCBIGRCm37mm9NCBIm37
MGSCv36715,468,160 - 15,476,856 (+)NCBImm8
Celera713,504,637 - 13,513,389 (+)NCBICelera
Cytogenetic Map7A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Bbc3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1552484
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.