Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) Mus musculus
Symbol: Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
CRRD ID: 1553000
Description: Exhibits several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Localizes to alpha-beta T cell receptor complex and cell-cell junction. Is expressed in central nervous system; embryo; midbrain; superior colliculus; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 70Z-SHP; hc; hcp; Hcph; hematopoietic cell protein-tyrosine phosphatase; hemopoietic cell phosphatase; me; motheaten; protein-tyrosine phosphatase 1C; Ptp; PTP-1C; Ptp1C; PTPTY-42; SH-PTP1; SH2 phosphatase 1; SHP; SHP-1; tyrosine-protein phosphatase non-receptor type 6
Homo sapiens (human) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptpn6 (protein tyrosine phosphatase, non-receptor type 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpn6 (protein tyrosine phosphatase non-receptor type 6)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Canis lupus familiaris (dog) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn6 (protein tyrosine phosphatase non-receptor type 6)
Sus scrofa (pig) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Chlorocebus sabaeus (African green monkey) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Heterocephalus glaber (naked mole-rat) : Ptpn6 (protein tyrosine phosphatase non-receptor type 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl6124,720,707 - 124,738,714 (-)EnsemblGRCm38mm10GRCm38
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBImm8
Celera6126,402,447 - 126,420,442 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptpn6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553000
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.