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Gene: Fasl (Fas ligand (TNF superfamily, member 6)) Mus musculus
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Symbol: Fasl
Name: Fas ligand (TNF superfamily, member 6)
Description: Predicted to have death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Localizes to external side of plasma membrane. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Orthologous to human FASLG (Fas ligand); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: APT1LG1; CD178; CD95 ligand; CD95-L; CD95L; Fas antigen ligand; Fas-L; Fas-Ligand; Faslg; generalized lymphoproliferative disease; gld; Tnfsf6; Tnlg1a; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand 1a; tumor necrosis factor ligand superfamily member 6
Orthologs:
Homo sapiens (human) : FASLG (Fas ligand)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Faslg (Fas ligand)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Faslg (Fas ligand)
Pan paniscus (bonobo/pygmy chimpanzee) : FASLG (Fas ligand)
Canis lupus familiaris (dog) : FASLG (Fas ligand)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Faslg (Fas ligand)
Sus scrofa (pig) : FASLG (Fas ligand (TNF superfamily, member 6))
Chlorocebus sabaeus (African green monkey) : FASLG (Fas ligand)
Heterocephalus glaber (naked mole-rat) : Faslg (Fas ligand)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBImm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Fasl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553064
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-05-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.