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Gene: Foxo3 (forkhead box O3) Mus musculus
Symbol: Foxo3
Name: forkhead box O3
CRRD ID: 1553155
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and positive regulation of cellular metabolic process. Localizes to several cellular components, including cytosol; mitochondrial outer membrane; and nucleus. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3); PARTICIPATES IN insulin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110048B16Rik; 2010203A17Rik; C76856; FKHR; Fkhr2; FKHRL1; forkhead box O3a; forkhead box protein O3; forkhead protein FKHR2; Fox; Foxo3a
Homo sapiens (human) : FOXO3 (forkhead box O3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Foxo3 (forkhead box O3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxo3 (forkhead box O3)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXO3 (forkhead box O3)
Canis lupus familiaris (dog) : FOXO3 (forkhead box O3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxo3 (forkhead box O3)
Sus scrofa (pig) : FOXO3 (forkhead box O3)
Chlorocebus sabaeus (African green monkey) : FOXO3 (forkhead box O3)
Heterocephalus glaber (naked mole-rat) : Foxo3 (forkhead box O3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1042,181,841 - 42,276,755 (-)EnsemblGRCm38mm10GRCm38
GRCm381042,181,845 - 42,276,695 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371041,905,592 - 41,996,548 (-)NCBIGRCm37mm9NCBIm37
MGSCv361041,874,201 - 41,965,157 (-)NCBImm8
Celera1043,062,294 - 43,153,032 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Foxo3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553155
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.