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Gene: Foxo3 (forkhead box O3) Mus musculus
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Symbol: Foxo3
Name: forkhead box O3
CRRD ID: 1553155
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and positive regulation of cellular metabolic process. Localizes to several cellular components, including cytosol; mitochondrial outer membrane; and nucleus. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3); PARTICIPATES IN insulin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110048B16Rik; 2010203A17Rik; C76856; FKHR; Fkhr2; FKHRL1; forkhead box O3a; forkhead box protein O3; forkhead protein FKHR2; Fox; Foxo3a
Orthologs:
Homo sapiens (human) : FOXO3 (forkhead box O3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Foxo3 (forkhead box O3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxo3 (forkhead box O3)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXO3 (forkhead box O3)
Canis lupus familiaris (dog) : FOXO3 (forkhead box O3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxo3 (forkhead box O3)
Sus scrofa (pig) : FOXO3 (forkhead box O3)
Chlorocebus sabaeus (African green monkey) : FOXO3 (forkhead box O3)
Heterocephalus glaber (naked mole-rat) : Foxo3 (forkhead box O3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1042,181,841 - 42,276,755 (-)EnsemblGRCm38mm10GRCm38
GRCm381042,181,845 - 42,276,695 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371041,905,592 - 41,996,548 (-)NCBIGRCm37mm9NCBIm37
MGSCv361041,874,201 - 41,965,157 (-)NCBImm8
Celera1043,062,294 - 43,153,032 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Foxo3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553155
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.