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Gene: Twist1 (twist basic helix-loop-helix transcription factor 1) Mus musculus
Symbol: Twist1
Name: twist basic helix-loop-helix transcription factor 1
CRRD ID: 1553211
Description: Exhibits several functions, including DNA-binding transcription factor activity; E-box binding activity; and protein homodimerization activity. Involved in several processes, including embryonic morphogenesis; heart development; and regulation of transcription, DNA-templated. Localizes to nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and genitourinary system. Used to study Saethre-Chotzen syndrome. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA960487; bHLHa; bHLHa38; charlie chaplin; M-Twi; M-Twist; MGC103391; pd; Pde; pdt; Pluri; Pluridigite; polydactyly EMS; Ska; Ska10; Ska; Skam10Jus; Twist; twist gene homolog 1; twist homolog 1; twist-related protein 1
Homo sapiens (human) : TWIST1 (twist family bHLH transcription factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Twist1 (twist family bHLH transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Twist1 (twist family bHLH transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TWIST1 (twist family bHLH transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Twist1 (twist family bHLH transcription factor 1)
Sus scrofa (pig) : TWIST1 (twist family bHLH transcription factor 1)
Chlorocebus sabaeus (African green monkey) : TWIST1 (twist family bHLH transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Twist1 (twist family bHLH transcription factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBImm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Twist1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553211
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.