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Gene: Casp4 (caspase 4, apoptosis-related cysteine peptidase) Mus musculus
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Symbol: Casp4
Name: caspase 4, apoptosis-related cysteine peptidase
Description: Predicted to have CARD domain binding activity; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; and scaffold protein binding activity. Involved in ectopic germ cell programmed cell death; positive regulation of interleukin-1 beta secretion; and pyroptosis. Predicted to localize to several cellular components, including AIM2 inflammasome complex; IPAF inflammasome complex; and NLRP3 inflammasome complex. Is expressed in several structures, including gut; lung; metanephros; reproductive system; and ureter. Orthologous to several human genes including CASP4 (caspase 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CASP-11; CASP-4; Casp11; caspase 11, apoptosis-related cysteine peptidase; caspase 11, apoptosis-related cysteine protease; caspase 4, apoptosis-related cysteine protease; caspase-11 short form splicing; caspase-4; Caspl; ich-3; protease ICH-3
Orthologs:
Homo sapiens (human) : CASP4 (caspase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Casp4 (caspase 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100991353 (caspase-4)
Canis lupus familiaris (dog) : CASP4 (caspase 4, apoptosis-related cysteine peptidase)
Sus scrofa (pig) : LOC100522887 (caspase-13)
Chlorocebus sabaeus (African green monkey) : CASP4 (caspase 4)
Heterocephalus glaber (naked mole-rat) : Casp4 (caspase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl95,308,828 - 5,336,783 (+)EnsemblGRCm38mm10GRCm38
GRCm3895,308,849 - 5,336,791 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3795,308,860 - 5,336,791 (+)NCBIGRCm37mm9NCBIm37
MGSCv3695,308,874 - 5,336,717 (+)NCBImm8
Celera3117,367,159 - 117,395,096 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Casp4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553228
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.