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Gene: Casp4 (caspase 4, apoptosis-related cysteine peptidase) Mus musculus
Symbol: Casp4
Name: caspase 4, apoptosis-related cysteine peptidase
Description: Predicted to have CARD domain binding activity; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; and scaffold protein binding activity. Involved in ectopic germ cell programmed cell death; positive regulation of interleukin-1 beta secretion; and pyroptosis. Predicted to localize to several cellular components, including AIM2 inflammasome complex; IPAF inflammasome complex; and NLRP3 inflammasome complex. Is expressed in several structures, including gut; lung; metanephros; reproductive system; and ureter. Orthologous to several human genes including CASP4 (caspase 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CASP-11; CASP-4; Casp11; caspase 11, apoptosis-related cysteine peptidase; caspase 11, apoptosis-related cysteine protease; caspase 4, apoptosis-related cysteine protease; caspase-11 short form splicing; caspase-4; Caspl; ich-3; protease ICH-3
Homo sapiens (human) : CASP4 (caspase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Casp4 (caspase 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100991353 (caspase-4)
Canis lupus familiaris (dog) : CASP4 (caspase 4, apoptosis-related cysteine peptidase)
Sus scrofa (pig) : LOC100522887 (caspase-13)
Chlorocebus sabaeus (African green monkey) : CASP4 (caspase 4)
Heterocephalus glaber (naked mole-rat) : Casp4 (caspase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl95,308,828 - 5,336,783 (+)EnsemblGRCm38mm10GRCm38
GRCm3895,308,849 - 5,336,791 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3795,308,860 - 5,336,791 (+)NCBIGRCm37mm9NCBIm37
MGSCv3695,308,874 - 5,336,717 (+)NCBImm8
Celera3117,367,159 - 117,395,096 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Casp4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553228
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.