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Gene: Smurf1 (SMAD specific E3 ubiquitin protein ligase 1) Mus musculus
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Symbol: Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Description: Predicted to have I-SMAD binding activity; R-SMAD binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of ossification; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; and protein ubiquitination. Predicted to colocalize with mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930431E10Rik; E3 ubiquitin-protein ligase SMURF1; HECT-type E3 ubiquitin transferase SMURF1; mKIAA1625; Smad ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1
Orthologs:
Homo sapiens (human) : SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)
Canis lupus familiaris (dog) : SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)
Sus scrofa (pig) : SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)
Chlorocebus sabaeus (African green monkey) : SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)
Heterocephalus glaber (naked mole-rat) : Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl5144,876,495 - 144,965,847 (-)EnsemblGRCm38mm10GRCm38
GRCm385144,876,495 - 144,965,899 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375145,637,364 - 145,726,699 (-)NCBIGRCm37mm9NCBIm37
MGSCv365145,130,022 - 145,219,357 (-)NCBImm8
MGSCv365143,961,853 - 144,051,632 (-)NCBImm8
Celera5141,867,627 - 141,904,898 (-)NCBICelera
Cytogenetic Map5G2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Smurf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553292
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.