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Gene: Prrx1 (paired related homeobox 1) Mus musculus
Symbol: Prrx1
Name: paired related homeobox 1
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and transcription coactivator activity. Involved in several processes, including embryonic morphogenesis; generation of neurons; and regulation of transcription by RNA polymerase II. Localizes to the nucleus. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human PRRX1 (paired related homeobox 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A230024N07Rik; AA755424; AI385634; AI843499; homeobox protein K-2; homeobox protein mHox; K-2; mHox; paired mesoderm homeobox 1; paired mesoderm homeobox protein 1; paired-related homeobox protein 1; Pmx; Pmx1; PRX-1; Prx1
Homo sapiens (human) : PRRX1 (paired related homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prrx1 (paired related homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prrx1 (paired related homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRRX1 (paired related homeobox 1)
Canis lupus familiaris (dog) : PRRX1 (paired related homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prrx1 (paired related homeobox 1)
Sus scrofa (pig) : PRRX1 (paired related homeobox 1)
Chlorocebus sabaeus (African green monkey) : PRRX1 (paired related homeobox 1)
Heterocephalus glaber (naked mole-rat) : Prrx1 (paired related homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1163,245,119 - 163,313,710 (-)EnsemblGRCm38mm10GRCm38
GRCm381163,245,119 - 163,315,145 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371165,175,250 - 165,243,781 (-)NCBIGRCm37mm9NCBIm37
MGSCv361165,081,794 - 165,150,325 (-)NCBImm8
Celera1165,686,221 - 165,753,419 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prrx1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553420
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.