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Gene: Prrx1 (paired related homeobox 1) Mus musculus
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Symbol: Prrx1
Name: paired related homeobox 1
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and transcription coactivator activity. Involved in several processes, including embryonic morphogenesis; generation of neurons; and regulation of transcription by RNA polymerase II. Localizes to the nucleus. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human PRRX1 (paired related homeobox 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A230024N07Rik; AA755424; AI385634; AI843499; homeobox protein K-2; homeobox protein mHox; K-2; mHox; paired mesoderm homeobox 1; paired mesoderm homeobox protein 1; paired-related homeobox protein 1; Pmx; Pmx1; PRX-1; Prx1
Orthologs:
Homo sapiens (human) : PRRX1 (paired related homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prrx1 (paired related homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prrx1 (paired related homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRRX1 (paired related homeobox 1)
Canis lupus familiaris (dog) : PRRX1 (paired related homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prrx1 (paired related homeobox 1)
Sus scrofa (pig) : PRRX1 (paired related homeobox 1)
Chlorocebus sabaeus (African green monkey) : PRRX1 (paired related homeobox 1)
Heterocephalus glaber (naked mole-rat) : Prrx1 (paired related homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1163,245,119 - 163,313,710 (-)EnsemblGRCm38mm10GRCm38
GRCm381163,245,119 - 163,315,145 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371165,175,250 - 165,243,781 (-)NCBIGRCm37mm9NCBIm37
MGSCv361165,081,794 - 165,150,325 (-)NCBImm8
Celera1165,686,221 - 165,753,419 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Prrx1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553420
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.