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Gene: Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2) Mus musculus
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Symbol: Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Description: Exhibits Ras guanyl-nucleotide exchange factor activity. Involved in several processes, including B cell homeostasis; regulation of T cell activation; and regulation of pro-B cell differentiation. Predicted to localize to the nucleosome. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; intestine; liver; and lung. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; interleukin-6 signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3',4,4',5-Pentachlorobiphenyl; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mSOS-2; son of sevenless homolog 2; son of sevenless homolog 2 (Drosophila); SOS-2
Orthologs:
Homo sapiens (human) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Canis lupus familiaris (dog) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Sus scrofa (pig) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Chlorocebus sabaeus (African green monkey) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Heterocephalus glaber (naked mole-rat) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1269,583,762 - 69,681,852 (-)EnsemblGRCm38mm10GRCm38
GRCm381269,583,761 - 69,681,852 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371270,684,748 - 70,782,839 (-)NCBIGRCm37mm9NCBIm37
MGSCv361270,502,366 - 70,604,506 (-)NCBImm8
Celera1270,672,614 - 70,748,402 (-)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Sos2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553448
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.