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Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Mus musculus
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Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Description: Exhibits steroid binding activity. Involved in several processes, including cellular sodium ion homeostasis; excretion; and regulation of synaptic vesicle exocytosis. Localizes to the GABA-ergic synapse and glutamatergic synapse. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2); PARTICIPATES IN aldosterone signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aldosterone receptor; mineralocorticoid receptor; Mlr; MR; nuclear receptor subfamily 3 group C member 2
Orthologs:
Homo sapiens (human) : NR3C2 (nuclear receptor subfamily 3 group C member 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nr3c2 (nuclear receptor subfamily 3, group C, member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr3c2 (nuclear receptor subfamily 3 group C member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR3C2 (nuclear receptor subfamily 3 group C member 2)
Canis lupus familiaris (dog) : NR3C2 (nuclear receptor subfamily 3 group C member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr3c2 (nuclear receptor subfamily 3 group C member 2)
Sus scrofa (pig) : NR3C2 (nuclear receptor subfamily 3 group C member 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38876,898,083 - 77,245,012 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37879,426,407 - 79,767,538 (+)NCBIGRCm37mm9NCBIm37
MGSCv36879,765,155 - 80,141,081 (+)NCBImm8
Celera881,194,433 - 81,532,459 (+)NCBICelera
Cytogenetic Map8 C1NCBI
cM Map836.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Nr3c2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553569
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.