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Gene: Notch4 (notch 4) Mus musculus
Symbol: Notch4
Name: notch 4
CRRD ID: 1553588
Description: Exhibits Notch binding activity. Involved in several processes, including blood vessel morphogenesis; negative regulation of Notch signaling pathway; and positive regulation of vasculature development. Localizes to cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: In; Int; Int-3; Int3; N; N4; neurogenic locus notch homolog protein 4; Notch gene homolog 4
Homo sapiens (human) : NOTCH4 (notch receptor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Notch4 (notch receptor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Notch4 (notch receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NOTCH4 (notch receptor 4)
Canis lupus familiaris (dog) : NOTCH4 (notch receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Notch4 (notch receptor 4)
Sus scrofa (pig) : NOTCH4 (notch receptor 4)
Chlorocebus sabaeus (African green monkey) : NOTCH4 (notch receptor 4)
Heterocephalus glaber (naked mole-rat) : Notch4 (notch receptor 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,783,257 - 34,807,517 (+)NCBI
GRCm381734,564,286 - 34,588,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,701,240 - 34,725,488 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,172,386 - 34,196,552 (+)NCBImm8
Celera1737,659,444 - 37,683,703 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Notch4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553588
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.