Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tcf3 (transcription factor 3) Mus musculus
Symbol: Tcf3
Name: transcription factor 3
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Contributes to E-box binding activity. Involved in several processes, including histone acetylation; immune system development; and positive regulation of macromolecule metabolic process. Localizes to the RNA polymerase II transcription factor complex and nuclear nucleosome. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Is expressed in several structures, including branchial arch; central nervous system; male reproductive system; retina; and urinary system. Orthologous to human TCF3 (transcription factor 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A1; AA408400; ALF2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; immunoglobulin enhancer-binding factor E12/E47; KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; transcription factor A1; transcription factor E2-alpha; transcription factor E2a; VDIR
Homo sapiens (human) : TCF3 (transcription factor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tcf3 (transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf3 (transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF3 (transcription factor 3)
Canis lupus familiaris (dog) : TCF3 (transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf3 (transcription factor 3)
Sus scrofa (pig) : TCF3 (transcription factor 3)
Chlorocebus sabaeus (green monkey) : TCF3 (transcription factor 3)
Heterocephalus glaber (naked mole-rat) : Tcf3 (transcription factor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1080,409,514 - 80,433,647 (-)Ensembl
GRCm381080,409,165 - 80,433,976 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371079,871,910 - 79,896,398 (-)NCBIGRCm37mm9NCBIm37
MGSCv361079,812,723 - 79,836,736 (-)NCBImm8
Celera1081,426,533 - 81,451,021 (-)NCBICelera
Cytogenetic Map10 C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tcf3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553595
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.