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Gene: Prf1 (perforin 1 (pore forming protein)) Mus musculus
Symbol: Prf1
Name: perforin 1 (pore forming protein)
Description: Exhibits calcium ion binding activity and wide pore channel activity. Involved in several processes, including T cell mediated cytotoxicity; defense response to tumor cell; and protein homooligomerization. Localizes to cytolytic granule; cytoplasmic vesicle; and integral component of membrane. Used to study familial hemophagocytic lymphohistiocytosis 2; multiple sclerosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 2-tert-butylhydroquinone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytolysin; lymphocyte pore-forming protein; P1; perforin-1; Pfn; Pfp; pore forming protein; Prf-1
Homo sapiens (human) : PRF1 (perforin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prf1 (perforin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prf1 (perforin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRF1 (perforin 1)
Canis lupus familiaris (dog) : PRF1 (perforin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prf1 (perforin 1)
Sus scrofa (pig) : PRF1 (perforin 1)
Chlorocebus sabaeus (African green monkey) : PRF1 (perforin 1)
Heterocephalus glaber (naked mole-rat) : Prf1 (perforin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1061,297,833 - 61,304,680 (+)EnsemblGRCm38mm10GRCm38
GRCm381061,297,751 - 61,304,684 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371060,760,584 - 60,767,011 (+)NCBIGRCm37mm9NCBIm37
MGSCv361060,693,191 - 60,699,667 (+)NCBImm8
Celera1062,399,002 - 62,405,430 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553597
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.