Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cd74 (CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)) Mus musculus
Symbol: Cd74
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Description: Exhibits MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including regulation of T cell differentiation; regulation of signal transduction; and thymic T cell selection. Localizes to several cellular components, including the NOS2-CD74 complex; macrophage migration inhibitory factor receptor complex; and multivesicular body. Colocalizes with the MHC class II protein complex. Is expressed in thymus primordium. Orthologous to human CD74 (CD74 molecule); PARTICIPATES IN antigen processing and presentation pathway; tuberculosis pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: class II-associated invariant chain peptide; CLIP; DHLAG; dinucleotide microsatellite; H-2 class II histocompatibility antigen gamma chain; histocompatibility: class II antigens, gamma chain of; HLA-DR-GAMMA; HLADG; ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; Ii; invariant polypeptide of major histocompatibility complex, class II antigen-associated; MHC class II-associated invariant chain
Homo sapiens (human) : CD74 (CD74 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd74 (CD74 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd74 (CD74 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD74 (CD74 molecule)
Canis lupus familiaris (dog) : CD74 (CD74 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd74 (CD74 molecule)
Sus scrofa (pig) : CD74 (CD74 molecule)
Chlorocebus sabaeus (African green monkey) : CD74 (CD74 molecule)
Heterocephalus glaber (naked mole-rat) : Cd74 (CD74 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1860,803,848 - 60,812,652 (+)Ensembl
GRCm381860,803,849 - 60,812,652 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371860,963,503 - 60,972,306 (+)NCBIGRCm37mm9NCBIm37
MGSCv361860,929,247 - 60,938,021 (+)NCBImm8
Celera1862,088,874 - 62,098,436 (+)NCBICelera
Cytogenetic Map18 E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cd74
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553657
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.