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Gene: F2rl1 (coagulation factor II (thrombin) receptor-like 1) Mus musculus
Symbol: F2rl1
Name: coagulation factor II (thrombin) receptor-like 1
CRRD ID: 1553673
Description: Exhibits G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including cytokine secretion; mature conventional dendritic cell differentiation; and positive regulation of intracellular signal transduction. Localizes to pseudopodium. Is expressed in several structures, including central nervous system; genitourinary system; gut; sensory organ; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1); PARTICIPATES IN protease mediated signaling via protease-activated receptor 2; sleeping sickness pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: coagulation factor II receptor-like 1; G-protein coupled receptor 11; Gpcr; Gpcr11; P; PA; PAR-2; Par2; Protease-activated receptor-2; proteinase-activated receptor 2; proteinase-activated receptor-2; thrombin receptor-like 1
Homo sapiens (human) : F2RL1 (F2R like trypsin receptor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : F2rl1 (F2R like trypsin receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2rl1 (F2R like trypsin receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : F2RL1 (F2R like trypsin receptor 1)
Canis lupus familiaris (dog) : F2RL1 (F2R like trypsin receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2rl1 (F2R like trypsin receptor 1)
Sus scrofa (pig) : F2RL1 (F2R like trypsin receptor 1)
Chlorocebus sabaeus (African green monkey) : F2RL1 (F2R like trypsin receptor 1)
Heterocephalus glaber (naked mole-rat) : F2rl1 (F2R like trypsin receptor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: Par2 (Gene ID: 109447) and F2rl1 (Gene ID: 14063) share the Par2 symbol/alias in common. Par2 is a widely used alternative name for coagulation factor II (thrombin) receptor-like 1 (F2rl1), which can be confused with the official symbol for Par2, pulmonary adenoma resistance 2 (Par2). [14 Aug 2020]
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1395,511,732 - 95,525,227 (-)EnsemblGRCm38mm10GRCm38
GRCm381395,511,718 - 95,525,240 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371396,281,673 - 96,295,195 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,612,431 - 96,634,965 (-)NCBImm8
Celera1399,130,515 - 99,143,639 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on F2rl1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553673
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.