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Gene: F2rl1 (coagulation factor II (thrombin) receptor-like 1) Mus musculus
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Symbol: F2rl1
Name: coagulation factor II (thrombin) receptor-like 1
CRRD ID: 1553673
Description: Exhibits G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including cytokine secretion; mature conventional dendritic cell differentiation; and positive regulation of intracellular signal transduction. Localizes to pseudopodium. Is expressed in several structures, including central nervous system; genitourinary system; gut; sensory organ; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1); PARTICIPATES IN protease mediated signaling via protease-activated receptor 2; sleeping sickness pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: coagulation factor II receptor-like 1; G-protein coupled receptor 11; Gpcr; Gpcr11; P; PA; PAR-2; Par2; Protease-activated receptor-2; proteinase-activated receptor 2; proteinase-activated receptor-2; thrombin receptor-like 1
Orthologs:
Homo sapiens (human) : F2RL1 (F2R like trypsin receptor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : F2rl1 (F2R like trypsin receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2rl1 (F2R like trypsin receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : F2RL1 (F2R like trypsin receptor 1)
Canis lupus familiaris (dog) : F2RL1 (F2R like trypsin receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2rl1 (F2R like trypsin receptor 1)
Sus scrofa (pig) : F2RL1 (F2R like trypsin receptor 1)
Chlorocebus sabaeus (African green monkey) : F2RL1 (F2R like trypsin receptor 1)
Heterocephalus glaber (naked mole-rat) : F2rl1 (F2R like trypsin receptor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: Par2 (Gene ID: 109447) and F2rl1 (Gene ID: 14063) share the Par2 symbol/alias in common. Par2 is a widely used alternative name for coagulation factor II (thrombin) receptor-like 1 (F2rl1), which can be confused with the official symbol for Par2, pulmonary adenoma resistance 2 (Par2). [14 Aug 2020]
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1395,511,732 - 95,525,227 (-)EnsemblGRCm38mm10GRCm38
GRCm381395,511,718 - 95,525,240 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371396,281,673 - 96,295,195 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,612,431 - 96,634,965 (-)NCBImm8
Celera1399,130,515 - 99,143,639 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on F2rl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1553673
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.