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Gene: Astl (astacin-like metalloendopeptidase (M12 family)) Mus musculus
Symbol: Astl
Name: astacin-like metalloendopeptidase (M12 family)
Description: Exhibits aspartic-type peptidase activity and glutamic-type peptidase activity. Involved in cell adhesion; negative regulation of fertilization; and positive regulation of protein processing. Localizes to the cortical granule and plasma membrane. Is expressed in early conceptus and oocyte. Orthologous to human ASTL (astacin like metalloendopeptidase); INTERACTS WITH bisphenol A; melatonin; Tributyltin oxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7420700F21; astacin-like metalloendopeptidase; C87576; MGC76457; oocyte astacin; ovastacin; Sas1b; sperm acrosomal SLLP1; sperm acrosomal SLLP1-binding protein
Homo sapiens (human) : ASTL (astacin like metalloendopeptidase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Astl (astacin like metalloendopeptidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Astl (astacin like metalloendopeptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : ASTL (astacin like metalloendopeptidase)
Canis lupus familiaris (dog) : ASTL (astacin like metalloendopeptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Astl (astacin like metalloendopeptidase)
Sus scrofa (pig) : ASTL (astacin like metalloendopeptidase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382127,338,639 - 127,357,655 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372127,164,375 - 127,183,387 (+)NCBIGRCm37mm9NCBIm37
MGSCv362127,030,080 - 127,049,092 (+)NCBImm8
Celera2128,583,915 - 128,599,929 (+)NCBICelera
Cytogenetic Map2 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Astl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1556969
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.