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Gene: Astl (astacin-like metalloendopeptidase (M12 family)) Mus musculus
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Symbol: Astl
Name: astacin-like metalloendopeptidase (M12 family)
Description: Exhibits aspartic-type peptidase activity and glutamic-type peptidase activity. Involved in cell adhesion; negative regulation of fertilization; and positive regulation of protein processing. Localizes to the cortical granule and plasma membrane. Is expressed in early conceptus and oocyte. Orthologous to human ASTL (astacin like metalloendopeptidase); INTERACTS WITH bisphenol A; melatonin; Tributyltin oxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7420700F21; astacin-like metalloendopeptidase; C87576; MGC76457; oocyte astacin; ovastacin; Sas1b; sperm acrosomal SLLP1; sperm acrosomal SLLP1-binding protein
Orthologs:
Homo sapiens (human) : ASTL (astacin like metalloendopeptidase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Astl (astacin like metalloendopeptidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Astl (astacin like metalloendopeptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : ASTL (astacin like metalloendopeptidase)
Canis lupus familiaris (dog) : ASTL (astacin like metalloendopeptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Astl (astacin like metalloendopeptidase)
Sus scrofa (pig) : ASTL (astacin like metalloendopeptidase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382127,338,639 - 127,357,655 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372127,164,375 - 127,183,387 (+)NCBIGRCm37mm9NCBIm37
MGSCv362127,030,080 - 127,049,092 (+)NCBImm8
Celera2128,583,915 - 128,599,929 (+)NCBICelera
Cytogenetic Map2 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Astl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1556969
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.