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Gene: Glis3 (GLIS family zinc finger 3) Mus musculus
Symbol: Glis3
Name: GLIS family zinc finger 3
Description: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 4833409N03Rik; E230012L24; E330013K21Rik; GLI-similar 3; Kruppel-like zinc finger protein Glis3; zinc finger protein GLIS3
Homo sapiens (human) : GLIS3 (GLIS family zinc finger 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Glis3 (GLIS family zinc finger 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glis3 (GLIS family zinc finger 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GLIS3 (GLIS family zinc finger 3)
Canis lupus familiaris (dog) : GLIS3 (GLIS family zinc finger 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glis3 (GLIS family zinc finger 3)
Sus scrofa (pig) : GLIS3 (GLIS family zinc finger 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381928,258,851 - 28,680,265 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371928,336,938 - 28,754,567 (-)NCBIGRCm37mm9NCBIm37
MGSCv361928,328,970 - 28,606,417 (-)NCBImm8
Celera1929,038,139 - 29,454,917 (-)NCBICelera
Cytogenetic Map19 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Glis3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557009
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.