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Gene: Mcph1 (microcephaly, primary autosomal recessive 1) Mus musculus
Symbol: Mcph1
Name: microcephaly, primary autosomal recessive 1
Description: Predicted to have identical protein binding activity. Involved in several processes, including establishment of mitotic spindle orientation; neuronal stem cell population maintenance; and regulation of organelle organization. Predicted to localize to the cytoplasm and cytoskeleton. Used to study microcephaly. Human ortholog(s) of this gene implicated in breast cancer; endometrial cancer; microcephaly; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 1. Is expressed in brain. Orthologous to human MCPH1 (microcephalin 1); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5430437K10Rik; BRIT1; D030046N04Rik; MCT; MGC66518; microcephalin; Tg(HLA-A2.1)1Enge
Homo sapiens (human) : MCPH1 (microcephalin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mcph1 (microcephalin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcph1 (microcephalin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MCPH1 (microcephalin 1)
Canis lupus familiaris (dog) : MCPH1 (microcephalin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcph1 (microcephalin 1)
Sus scrofa (pig) : MCPH1 (microcephalin 1)
Chlorocebus sabaeus (African green monkey) : MCPH1 (microcephalin 1)
Heterocephalus glaber (naked mole-rat) : Mcph1 (microcephalin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl818,595,131 - 18,803,189 (+)Ensembl
GRCm38818,595,116 - 18,808,089 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37818,595,173 - 18,803,189 (+)NCBIGRCm37mm9NCBIm37
MGSCv36818,595,150 - 18,803,166 (+)NCBImm8
Celera818,728,614 - 18,936,696 (+)NCBICelera
Cytogenetic Map8 A1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mcph1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557042
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.