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Gene: Mcph1 (microcephaly, primary autosomal recessive 1) Mus musculus
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Symbol: Mcph1
Name: microcephaly, primary autosomal recessive 1
Description: Predicted to have identical protein binding activity. Involved in several processes, including establishment of mitotic spindle orientation; neuronal stem cell population maintenance; and regulation of organelle organization. Predicted to localize to the cytoplasm and cytoskeleton. Used to study microcephaly. Human ortholog(s) of this gene implicated in breast cancer; endometrial cancer; microcephaly; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 1. Is expressed in brain. Orthologous to human MCPH1 (microcephalin 1); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5430437K10Rik; BRIT1; D030046N04Rik; MCT; MGC66518; microcephalin; Tg(HLA-A2.1)1Enge
Orthologs:
Homo sapiens (human) : MCPH1 (microcephalin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mcph1 (microcephalin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcph1 (microcephalin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MCPH1 (microcephalin 1)
Canis lupus familiaris (dog) : MCPH1 (microcephalin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcph1 (microcephalin 1)
Sus scrofa (pig) : MCPH1 (microcephalin 1)
Chlorocebus sabaeus (African green monkey) : MCPH1 (microcephalin 1)
Heterocephalus glaber (naked mole-rat) : Mcph1 (microcephalin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl818,595,131 - 18,803,189 (+)Ensembl
GRCm38818,595,116 - 18,808,089 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37818,595,173 - 18,803,189 (+)NCBIGRCm37mm9NCBIm37
MGSCv36818,595,150 - 18,803,166 (+)NCBImm8
Celera818,728,614 - 18,936,696 (+)NCBICelera
Cytogenetic Map8 A1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mcph1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557042
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.