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Gene: Pml (promyelocytic leukemia) Mus musculus
Symbol: Pml
Name: promyelocytic leukemia
Description: Exhibits SMAD binding activity. Involved in several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the cytosol; extrinsic component of endoplasmic reticulum membrane; and nuclear lumen. Colocalizes with the heterochromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human PML (promyelocytic leukemia); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200009E24Rik; AI661194; probable transcription factor PML; Trim19
Homo sapiens (human) : PML (promyelocytic leukemia)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pml (promyelocytic leukemia)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pml (promyelocytic leukemia)
Pan paniscus (bonobo/pygmy chimpanzee) : PML (promyelocytic leukemia)
Canis lupus familiaris (dog) : PML (promyelocytic leukemia)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pml (promyelocytic leukemia)
Sus scrofa (pig) : PML (promyelocytic leukemia)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38958,217,179 - 58,249,796 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37958,064,986 - 58,097,593 (-)NCBIGRCm37mm9NCBIm37
MGSCv36958,016,679 - 58,047,923 (-)NCBImm8
Celera955,451,359 - 55,484,054 (-)NCBICelera
Cytogenetic Map9 BNCBI
cM Map931.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pml
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557220
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.