2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PML mRNA CTD PMID:19933214 , PMID:21889950 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:25975270 , PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PML mRNA CTD PMID:21570461 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:1562602 6480464 tetrabromobisphenol A results in increased expression of PML mRNA CTD PMID:27914987 3-methyladenine multiple interactions ISO RGD:1345145 6480464 3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] CTD PMID:28130038 4'-epidoxorubicin affects mutagenesis ISO RGD:1345145 6480464 Epirubicin affects the mutagenesis of PML gene CTD PMID:19884644 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PML mRNA CTD PMID:18648102 5-azacytidine increases expression ISO RGD:1345145 6480464 Azacitidine results in increased expression of PML mRNA CTD PMID:19194470 6-propyl-2-thiouracil affects expression ISO RGD:1562602 6480464 Propylthiouracil affects the expression of PML mRNA CTD PMID:24780913 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions EXP 6480464 PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein] more ... CTD PMID:23430110 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of PML mRNA CTD PMID:19770486 aflatoxin B1 increases expression ISO RGD:1345145 6480464 Aflatoxin B1 results in increased expression of PML mRNA CTD PMID:21641981 all-trans-retinoic acid affects localization ISO RGD:1345145 6480464 Tretinoin affects the localization of PML protein CTD PMID:9834237 all-trans-retinoic acid increases degradation ISO RGD:1345145 6480464 Tretinoin results in increased degradation of PML protein mutant form CTD PMID:15748426 more ... all-trans-retinoic acid increases phosphorylation ISO RGD:1345145 6480464 Tretinoin results in increased phosphorylation of PML protein mutant form CTD PMID:19029980 all-trans-retinoic acid decreases expression ISO RGD:1345145 6480464 Tretinoin results in decreased expression of PML mRNA CTD PMID:16249480 all-trans-retinoic acid increases cleavage ISO RGD:1345145 6480464 Tretinoin results in increased cleavage of PML protein mutant form CTD PMID:12130515 all-trans-retinoic acid increases expression ISO RGD:1345145 6480464 Tretinoin results in increased expression of PML protein CTD PMID:12015078 all-trans-retinoic acid multiple interactions ISO RGD:1345145 6480464 [Tretinoin co-treated with arsenic trioxide] results in decreased expression of PML mRNA alternative form more ... CTD PMID:12130515 more ... aluminium sulfate (anhydrous) multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with aluminum sulfate] results in increased expression of PML protein CTD PMID:23430110 amphetamine decreases expression ISO RGD:1562602 6480464 Amphetamine results in decreased expression of PML mRNA CTD PMID:30779732 Antimony trioxide affects localization ISO RGD:1345145 6480464 antimony trioxide affects the localization of PML protein CTD PMID:9834237 Antimony trioxide increases degradation ISO RGD:1345145 6480464 antimony trioxide results in increased degradation of PML protein mutant form CTD PMID:9834237 Antimony trioxide multiple interactions ISO RGD:1345145 6480464 antimony trioxide promotes the reaction [SUMO1 protein binds to PML protein] CTD PMID:9834237 antimony(0) multiple interactions ISO RGD:1345145 6480464 Antimony affects the localization of and results in increased sumoylation of PML protein CTD PMID:26049103 Aroclor 1254 decreases expression ISO RGD:1345145 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of PML mRNA CTD PMID:16934159 arsane increases degradation ISO RGD:1345145 6480464 Arsenic results in increased degradation of PML protein CTD PMID:18408734 arsane multiple interactions ISO RGD:1345145 6480464 RNF4 protein promotes the reaction [Arsenic results in increased degradation of PML protein] CTD PMID:18408734 arsenic atom multiple interactions ISO RGD:1345145 6480464 RNF4 protein promotes the reaction [Arsenic results in increased degradation of PML protein] CTD PMID:18408734 arsenic atom increases degradation ISO RGD:1345145 6480464 Arsenic results in increased degradation of PML protein CTD PMID:18408734 arsenite(3-) increases response to substance ISO RGD:1345145 6480464 PML protein results in increased susceptibility to arsenite CTD PMID:24135626 arsenite(3-) increases sumoylation ISO RGD:1345145 6480464 arsenite results in increased sumoylation of PML protein CTD PMID:24135626 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PML protein CTD PMID:18469801 arsenous acid affects localization ISO RGD:1345145 6480464 Arsenic Trioxide affects the localization of PML protein CTD PMID:15622748 more ... arsenous acid multiple interactions ISO RGD:1345145 6480464 [[Arsenic Trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]] which results in increased degradation of PML protein alternative form more ... CTD PMID:15093545 more ... arsenous acid increases degradation EXP 6480464 Arsenic Trioxide results in increased degradation of PML protein CTD PMID:21921037 , PMID:23430110 arsenous acid decreases response to substance ISO RGD:1345145 6480464 PML gene mutant form results in decreased susceptibility to Arsenic Trioxide more ... CTD PMID:21613260 more ... arsenous acid affects response to substance ISO RGD:1345145 6480464 PML protein affects the susceptibility to Arsenic Trioxide CTD PMID:21217775 arsenous acid increases ubiquitination ISO RGD:1345145 6480464 Arsenic Trioxide results in increased ubiquitination of PML protein, Arsenic Trioxide results in increased ubiquitination of PML protein alternative form CTD PMID:20378816 , PMID:23028697 arsenous acid affects metabolic processing ISO RGD:1345145 6480464 Arsenic Trioxide affects the metabolism of PML protein CTD PMID:21217775 arsenous acid decreases expression ISO RGD:1345145 6480464 Arsenic Trioxide results in decreased expression of PML mRNA mutant form more ... CTD PMID:11721366 more ... arsenous acid multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [Bleomycin results in increased expression of PML protein], Arsenic Trioxide results in increased sumoylation of and results in increased localization of and results in increased degradation of [PML protein mutant form binds to PML protein mutant form] CTD PMID:20609355 , PMID:24762191 arsenous acid increases sumoylation ISO RGD:1345145 6480464 Arsenic Trioxide results in increased sumoylation of PML protein, Arsenic Trioxide results in increased sumoylation of PML protein alternative form CTD PMID:17081986 more ... arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of PML mRNA CTD PMID:21921037 arsenous acid affects binding ISO RGD:1345145 6480464 Arsenic Trioxide binds to PML protein, Arsenic Trioxide binds to PML protein modified form CTD PMID:15748426 , PMID:20378816 arsenous acid increases expression ISO RGD:1345145 6480464 Arsenic Trioxide results in increased expression of PML protein modified form CTD PMID:20943951 arsenous acid increases degradation ISO RGD:1345145 6480464 Arsenic Trioxide results in increased degradation of PML protein, Arsenic Trioxide results in increased degradation of PML protein mutant form CTD PMID:15748426 more ... arsenous acid increases response to substance ISO RGD:1345145 6480464 PML mutant form results in increased susceptibility to Arsenic Trioxide CTD PMID:26118777 ATP multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein] more ... CTD PMID:23430110 benzo[a]pyrene increases mutagenesis ISO RGD:1345145 6480464 Benzo(a)pyrene results in increased mutagenesis of PML gene CTD PMID:25435355 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of PML mRNA CTD PMID:22228805 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PML mRNA CTD PMID:19770486 more ... bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A affects expression ISO RGD:1562602 6480464 bisphenol A affects the expression of PML mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of PML protein CTD PMID:24762191 bleomycin A2 multiple interactions EXP 6480464 arsenic trioxide inhibits the reaction [Bleomycin results in increased expression of PML protein] CTD PMID:24762191 buta-1,3-diene decreases expression EXP 6480464 1, 3-butadiene results in decreased expression of PML mRNA CTD PMID:29038090 cadmium dichloride multiple interactions EXP 6480464 PML gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 protein], PML protein affects the reaction [Cadmium Chloride affects the localization of CCND1 mRNA] CTD PMID:12167712 cadmium dichloride affects localization EXP 6480464 Cadmium Chloride affects the localization of PML protein CTD PMID:12167712 calciol multiple interactions ISO RGD:1345145 6480464 PML protein mutant form inhibits the reaction [[Cholecalciferol co-treated with TGFB1 protein] results in increased expression of CD14 mRNA] CTD PMID:15988048 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of PML mRNA, Nanotubes, Carbon results in increased expression of PML mRNA CTD PMID:25554681 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of PML mRNA CTD PMID:21151649 cisplatin multiple interactions ISO RGD:1345145 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of PML mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:1345145 6480464 Cisplatin results in increased expression of PML mRNA CTD PMID:27392435 cobalt dichloride multiple interactions ISO RGD:1345145 6480464 cobaltous chloride promotes the reaction [arsenic trioxide results in increased degradation of PML protein mutant form] CTD PMID:16330433 cycloheximide decreases degradation ISO RGD:1345145 6480464 Cycloheximide results in decreased degradation of PML protein modified form CTD PMID:26049103 cycloheximide multiple interactions ISO RGD:1345145 6480464 Cycloheximide inhibits the reaction [arsenic trioxide results in increased degradation of PML protein] CTD PMID:20943951 DAPT multiple interactions ISO RGD:1345145 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] CTD PMID:28130038 deoxynivalenol decreases phosphorylation EXP 6480464 deoxynivalenol results in decreased phosphorylation of PML protein CTD PMID:23811945 deoxynivalenol affects phosphorylation EXP 6480464 deoxynivalenol affects the phosphorylation of PML protein CTD PMID:23352502 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PML protein CTD PMID:18469801 diarsenic trioxide affects response to substance ISO RGD:1345145 6480464 PML protein affects the susceptibility to Arsenic Trioxide CTD PMID:21217775 diarsenic trioxide affects binding ISO RGD:1345145 6480464 Arsenic Trioxide binds to PML protein, Arsenic Trioxide binds to PML protein modified form CTD PMID:15748426 , PMID:20378816 diarsenic trioxide decreases expression ISO RGD:1345145 6480464 Arsenic Trioxide results in decreased expression of PML mRNA mutant form more ... CTD PMID:11721366 more ... diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of PML mRNA CTD PMID:21921037 diarsenic trioxide increases response to substance ISO RGD:1345145 6480464 PML mutant form results in increased susceptibility to Arsenic Trioxide CTD PMID:26118777 diarsenic trioxide affects localization ISO RGD:1345145 6480464 Arsenic Trioxide affects the localization of PML protein CTD PMID:15622748 more ... diarsenic trioxide multiple interactions ISO RGD:1345145 6480464 [[Arsenic Trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]] which results in increased degradation of PML protein alternative form more ... CTD PMID:15093545 more ... diarsenic trioxide decreases response to substance ISO RGD:1345145 6480464 PML gene mutant form results in decreased susceptibility to Arsenic Trioxide more ... CTD PMID:21613260 more ... diarsenic trioxide increases ubiquitination ISO RGD:1345145 6480464 Arsenic Trioxide results in increased ubiquitination of PML protein, Arsenic Trioxide results in increased ubiquitination of PML protein alternative form CTD PMID:20378816 , PMID:23028697 diarsenic trioxide increases degradation EXP 6480464 Arsenic Trioxide results in increased degradation of PML protein CTD PMID:21921037 , PMID:23430110 diarsenic trioxide affects metabolic processing ISO RGD:1345145 6480464 Arsenic Trioxide affects the metabolism of PML protein CTD PMID:21217775 diarsenic trioxide increases degradation ISO RGD:1345145 6480464 Arsenic Trioxide results in increased degradation of PML protein, Arsenic Trioxide results in increased degradation of PML protein mutant form CTD PMID:15748426 more ... diarsenic trioxide multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [Bleomycin results in increased expression of PML protein], Arsenic Trioxide results in increased sumoylation of and results in increased localization of and results in increased degradation of [PML protein mutant form binds to PML protein mutant form] CTD PMID:20609355 , PMID:24762191 diarsenic trioxide increases expression ISO RGD:1345145 6480464 Arsenic Trioxide results in increased expression of PML protein modified form CTD PMID:20943951 diarsenic trioxide increases sumoylation ISO RGD:1345145 6480464 Arsenic Trioxide results in increased sumoylation of PML protein, Arsenic Trioxide results in increased sumoylation of PML protein alternative form CTD PMID:17081986 more ... dicrotophos increases expression ISO RGD:1345145 6480464 dicrotophos results in increased expression of PML mRNA CTD PMID:28302478 dimercaprol multiple interactions ISO RGD:1345145 6480464 Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to PML protein] CTD PMID:26598702 dimethylarsinous acid multiple interactions ISO RGD:1345145 6480464 [monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased degradation of PML protein CTD PMID:29774349 dioxygen affects methylation EXP 6480464 Oxygen deficiency affects the methylation of PML promoter CTD PMID:24205000 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of PML mRNA CTD PMID:24205000 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases degradation ISO RGD:1345145 6480464 Antimony Potassium Tartrate results in increased degradation of PML protein mutant form CTD PMID:9834237 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate affects localization ISO RGD:1345145 6480464 Antimony Potassium Tartrate affects the localization of PML protein CTD PMID:9834237 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions ISO RGD:1345145 6480464 Antimony Potassium Tartrate promotes the reaction [SUMO1 protein binds to PML protein] CTD PMID:9834237 dorsomorphin multiple interactions ISO RGD:1345145 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PML mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1345145 6480464 Doxorubicin results in decreased expression of PML mRNA CTD PMID:29803840 elemental selenium multiple interactions ISO RGD:1345145 6480464 [Selenium co-treated with Vitamin E] results in increased expression of PML mRNA CTD PMID:19244175 elemental selenium increases expression ISO RGD:1345145 6480464 Selenium results in increased expression of PML mRNA CTD PMID:19244175 ellagic acid decreases expression ISO RGD:1345145 6480464 Ellagic Acid results in decreased expression of PML mRNA CTD PMID:12002526 endosulfan decreases expression ISO RGD:1562602 6480464 Endosulfan results in decreased expression of PML mRNA CTD PMID:29391264 enzyme inhibitor multiple interactions ISO RGD:1345145 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PML protein CTD PMID:23301498 erlotinib hydrochloride increases localization ISO RGD:1345145 6480464 Erlotinib Hydrochloride results in increased localization of PML protein CTD PMID:23440206 erlotinib hydrochloride decreases response to substance ISO RGD:1345145 6480464 PML protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23440206 erlotinib hydrochloride increases expression ISO RGD:1345145 6480464 Erlotinib Hydrochloride results in increased expression of PML protein CTD PMID:23440206 ethyl methanesulfonate increases expression ISO RGD:1345145 6480464 Ethyl Methanesulfonate results in increased expression of PML mRNA CTD PMID:23649840 fenamidone increases expression EXP 6480464 fenamidone results in increased expression of PML mRNA CTD PMID:27029645 fenvalerate affects methylation EXP 6480464 fenvalerate affects the methylation of PML gene CTD PMID:23548413 fluoranthene multiple interactions EXP 6480464 [1-methylanthracene co-treated with fluoranthene] results in decreased expression of PML mRNA CTD PMID:28329830 Ginkgoic acid decreases response to substance EXP 6480464 PML protein results in decreased susceptibility to ginkgolic acid CTD PMID:29524504 Ginkgoic acid multiple interactions EXP 6480464 ginkgolic acid inhibits the reaction [AGT protein modified form results in increased sumoylation of PML protein] more ... CTD PMID:29524504 hydroxyurea increases expression EXP 6480464 Hydroxyurea results in increased expression of PML mRNA CTD PMID:27208086 ibuprofen affects expression ISO RGD:1345145 6480464 Ibuprofen affects the expression of PML mRNA CTD PMID:17070997 leptomycin B multiple interactions EXP 6480464 leptomycin B inhibits the reaction [Lipopolysaccharides results in increased localization of PML protein] CTD PMID:23430110 lipopolysaccharide multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein] more ... CTD PMID:23430110 lipopolysaccharide increases expression ISO RGD:1345145 6480464 Lipopolysaccharides results in increased expression of PML protein CTD PMID:30501627 lipopolysaccharide increases localization EXP 6480464 Lipopolysaccharides results in increased localization of PML protein CTD PMID:23430110 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of PML mRNA, Lipopolysaccharides results in increased expression of PML protein CTD PMID:12057914 , PMID:23430110 methyl methanesulfonate increases expression ISO RGD:1345145 6480464 Methyl Methanesulfonate results in increased expression of PML mRNA CTD PMID:23649840 mitoxantrone affects mutagenesis ISO RGD:1345145 6480464 Mitoxantrone affects the mutagenesis of PML gene CTD PMID:19884644 N-(6-acetamidohexyl)acetamide multiple interactions ISO RGD:1345145 6480464 [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of PML protein mutant form CTD PMID:12130515 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases degradation ISO RGD:1345145 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PML protein modified form CTD PMID:26049103 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of PML mRNA CTD PMID:17854601 N-nitrosodiethylamine multiple interactions EXP 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PML mRNA] CTD PMID:17854601 nickel atom increases expression ISO RGD:1345145 6480464 Nickel results in increased expression of PML mRNA CTD PMID:24768652 , PMID:25583101 p-menthan-3-ol decreases expression ISO RGD:1345145 6480464 Menthol results in decreased expression of PML mRNA CTD PMID:26760959 paraquat multiple interactions EXP 6480464 Paraquat promotes the reaction [PML protein binds to PML protein], Paraquat results in increased sumoylation of and results in increased localization of and results in increased degradation of [PML protein mutant form binds to PML protein mutant form] CTD PMID:20609355 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of PML mRNA CTD PMID:23892564 phenylmercury acetate multiple interactions ISO RGD:1345145 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PML mRNA CTD PMID:27188386 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PML mRNA CTD PMID:17426115 propiconazole decreases expression EXP 6480464 propiconazole results in decreased expression of PML mRNA CTD PMID:21278054 puerarin multiple interactions ISO RGD:1345145 6480464 arsenic trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form] CTD PMID:20416161 puerarin decreases expression ISO RGD:1345145 6480464 puerarin results in decreased expression of PML mRNA alternative form CTD PMID:20416161 reactive oxygen species multiple interactions EXP 6480464 PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased abundance of Reactive Oxygen Species] CTD PMID:23430110 resiquimod multiple interactions EXP 6480464 PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein] CTD PMID:23430110 resveratrol multiple interactions ISO RGD:1345145 6480464 BCL2 protein inhibits the reaction [resveratrol promotes the reaction [PML protein binds to CREBBP protein]] more ... CTD PMID:19631782 resveratrol increases expression ISO RGD:1345145 6480464 resveratrol results in increased expression of PML mRNA CTD PMID:25436977 rofecoxib increases expression ISO RGD:1345145 6480464 rofecoxib results in increased expression of PML mRNA CTD PMID:17070997 SB 431542 multiple interactions ISO RGD:1345145 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PML mRNA CTD PMID:27188386 selenium atom multiple interactions ISO RGD:1345145 6480464 [Selenium co-treated with Vitamin E] results in increased expression of PML mRNA CTD PMID:19244175 selenium atom increases expression ISO RGD:1345145 6480464 Selenium results in increased expression of PML mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:1345145 6480464 Silicon Dioxide analog results in decreased expression of PML mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:1345145 6480464 Silicon Dioxide results in increased expression of PML mRNA CTD PMID:25351596 silver atom decreases expression EXP 6480464 Silver results in decreased expression of PML mRNA CTD PMID:27131904 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of PML mRNA CTD PMID:27131904 sirolimus increases expression ISO RGD:1345145 6480464 Sirolimus results in increased expression of PML protein CTD PMID:23440206 sirolimus increases localization ISO RGD:1345145 6480464 Sirolimus results in increased localization of PML protein CTD PMID:23440206 sirolimus decreases response to substance ISO RGD:1345145 6480464 PML protein results in decreased susceptibility to Sirolimus CTD PMID:23440206 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of PML mRNA CTD PMID:21795629 sodium arsenite multiple interactions ISO RGD:1345145 6480464 sodium arsenite affects the localization of and results in increased sumoylation of PML protein CTD PMID:26049103 sodium arsenite decreases expression ISO RGD:1345145 6480464 sodium arsenite results in decreased expression of PML mRNA CTD PMID:12016162 sulindac increases expression ISO RGD:1345145 6480464 Sulindac results in increased expression of PML mRNA CTD PMID:16273229 tetrachloromethane decreases expression ISO RGD:1562602 6480464 Carbon Tetrachloride results in decreased expression of PML mRNA CTD PMID:31150632 thimerosal decreases expression ISO RGD:1345145 6480464 Thimerosal results in decreased expression of PML mRNA CTD PMID:27188386 titanium dioxide increases expression ISO RGD:1345145 6480464 titanium dioxide results in increased expression of PML protein CTD PMID:30910687 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of PML mRNA CTD PMID:28973697 tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of PML mRNA CTD PMID:30912803 valproic acid decreases expression ISO RGD:1345145 6480464 Valproic Acid results in decreased expression of PML mRNA CTD PMID:29154799 valproic acid increases expression ISO RGD:1345145 6480464 Valproic Acid results in increased expression of PML mRNA CTD PMID:28001369 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of PML mRNA CTD PMID:17963808 vanadyl sulfate decreases expression ISO RGD:1345145 6480464 vanadyl sulfate results in decreased expression of PML mRNA CTD PMID:16330358 vitamin E multiple interactions ISO RGD:1345145 6480464 [Selenium co-treated with Vitamin E] results in increased expression of PML mRNA CTD PMID:19244175 vitamin E increases expression ISO RGD:1345145 6480464 Vitamin E results in increased expression of PML mRNA CTD PMID:19244175 vorinostat multiple interactions ISO RGD:1345145 6480464 [vorinostat co-treated with arsenic trioxide] results in decreased expression of PML protein mutant form more ... CTD PMID:19631782 , PMID:27189198 vorinostat decreases expression ISO RGD:1345145 6480464 vorinostat results in decreased expression of PML protein mutant form CTD PMID:27189198 zebularine decreases expression ISO RGD:1345145 6480464 pyrimidin-2-one beta-ribofuranoside results in decreased expression of PML mRNA CTD PMID:19194470 zinc atom increases expression ISO RGD:1345145 6480464 Zinc results in increased expression of PML protein mutant form CTD PMID:16330433 zinc(0) increases expression ISO RGD:1345145 6480464 Zinc results in increased expression of PML protein mutant form CTD PMID:16330433
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process IMP MGI:MGI:2429949 2290270 (MGI:MGI:1306978, PMID:9806545) MGI MGI:MGI:1306978 , PMID:9806545 apoptotic process ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 branching involved in mammary gland duct morphogenesis IMP MGI:MGI:2429949 2290270 (MGI:MGI:3839212, PMID:19261859) MGI MGI:MGI:3839212 , PMID:19261859 cell aging IMP 2290270 (MGI:MGI:3717518, PMID:10910364) UniProtKB MGI:MGI:3717518 , PMID:10910364 cell cycle arrest ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cell cycle arrest IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cell cycle arrest IMP 2290270 (MGI:MGI:3717518, PMID:10910364) UniProtKB MGI:MGI:3717518 , PMID:10910364 cell fate commitment IMP MGI:MGI:2429949 2290270 (MGI:MGI:3839212, PMID:19261859) MGI MGI:MGI:3839212 , PMID:19261859 cellular response to interleukin-4 IDA 2290270 (MGI:MGI:1859302, PMID:9798653) MGI MGI:MGI:1859302 , PMID:9798653 cellular response to leukemia inhibitory factor IEP 2290270 (MGI:MGI:4822296, PMID:20439489) MGI MGI:MGI:4822296 , PMID:20439489 cellular senescence ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 circadian regulation of gene expression IDA 2290270 (MGI:MGI:5314433, PMID:22274616) UniProtKB MGI:MGI:5314433 , PMID:22274616 common-partner SMAD protein phosphorylation IMP MGI:MGI:2429949 2290270 (MGI:MGI:3054278, PMID:15356634) MGI MGI:MGI:3054278 , PMID:15356634 defense response to virus IEA UniProtKB-KW:KW-0051 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP 2290270 (MGI:MGI:3580934, PMID:15626733) UniProtKB MGI:MGI:3580934 , PMID:15626733 endoplasmic reticulum calcium ion homeostasis IMP 2290270 (MGI:MGI:4849347, PMID:21030605) UniProtKB MGI:MGI:4849347 , PMID:21030605 entrainment of circadian clock by photoperiod IDA 2290270 (MGI:MGI:5314433, PMID:22274616) UniProtKB MGI:MGI:5314433 , PMID:22274616 extrinsic apoptotic signaling pathway IMP MGI:MGI:2429949 2290270 (MGI:MGI:1306978, PMID:9806545) MGI MGI:MGI:1306978 , PMID:9806545 fibroblast migration IMP 2290270 (MGI:MGI:5502477, PMID:23555679) CACAO MGI:MGI:5502477 , PMID:23555679 immune system process IEA UniProtKB-KW:KW-0391 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 innate immune response ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 innate immune response IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 innate immune response IDA 2290270 (MGI:MGI:5545996, PMID:18248090) UniProtKB MGI:MGI:5545996 , PMID:18248090 intrinsic apoptotic signaling pathway by p53 class mediator IMP 2290270 (MGI:MGI:3034149, PMID:14992722) MGI MGI:MGI:3034149 , PMID:14992722 intrinsic apoptotic signaling pathway in response to DNA damage IMP MGI:MGI:2429949 2290270 (MGI:MGI:1306978, PMID:9806545) MGI MGI:MGI:1306978 , PMID:9806545 intrinsic apoptotic signaling pathway in response to DNA damage IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 intrinsic apoptotic signaling pathway in response to DNA damage ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 intrinsic apoptotic signaling pathway in response to DNA damage IMP MGI:MGI:104662 2290270 (MGI:MGI:3580934, PMID:15626733) MGI MGI:MGI:3580934 , PMID:15626733 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP 2290270 (MGI:MGI:3580934, PMID:15626733) UniProtKB MGI:MGI:3580934 , PMID:15626733 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP 2290270 (MGI:MGI:4849347, PMID:21030605) MGI MGI:MGI:4849347 , PMID:21030605 intrinsic apoptotic signaling pathway in response to oxidative stress IMP 2290270 (MGI:MGI:4849347, PMID:21030605) MGI MGI:MGI:4849347 , PMID:21030605 maintenance of protein location in nucleus ISO UniProtKB:P29590 2290270 (MGI:MGI:3763815, PMID:17332504) MGI MGI:MGI:3763815 , PMID:17332504 myeloid cell differentiation IMP MGI:MGI:2429949 2290270 (MGI:MGI:1197798, PMID:9488655) MGI MGI:MGI:1197798 , PMID:9488655 negative regulation of angiogenesis IMP MGI:MGI:2429949 2290270 (MGI:MGI:3654795, PMID:16915281) MGI MGI:MGI:3654795 , PMID:16915281 negative regulation of angiogenesis ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of cell growth ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of cell population proliferation IMP MGI:MGI:2429949 2290270 (MGI:MGI:1197798, PMID:9488655) MGI MGI:MGI:1197798 , PMID:9488655 negative regulation of cell population proliferation ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of interleukin-1 beta secretion IMP 2290270 (MGI:MGI:5621259, PMID:24407287) AgBase MGI:MGI:5621259 , PMID:24407287 negative regulation of interleukin-1 secretion IMP 2290270 (MGI:MGI:5621259, PMID:24407287) AgBase MGI:MGI:5621259 , PMID:24407287 negative regulation of mitotic cell cycle ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of telomerase activity ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of telomere maintenance via telomerase ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription, DNA-templated ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of translation in response to oxidative stress ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of ubiquitin-dependent protein catabolic process ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of viral release from host cell ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of viral release from host cell IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 negative regulation of viral release from host cell IDA 2290270 (MGI:MGI:5545996, PMID:18248090) UniProtKB MGI:MGI:5545996 , PMID:18248090 PML body organization IDA 2290270 (MGI:MGI:2449749, PMID:12529400) MGI MGI:MGI:2449749 , PMID:12529400 PML body organization IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 PML body organization ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of apoptotic process involved in mammary gland involution ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of apoptotic signaling pathway IGI MGI:MGI:1197015 2290270 (MGI:MGI:4942266, PMID:10684855) MGI MGI:MGI:4942266 , PMID:10684855 positive regulation of apoptotic signaling pathway IMP 2290270 (MGI:MGI:4942266, PMID:10684855) MGI MGI:MGI:4942266 , PMID:10684855 positive regulation of defense response to virus by host ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of extrinsic apoptotic signaling pathway ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of fibroblast proliferation IMP 2290270 (MGI:MGI:5502477, PMID:23555679) CACAO MGI:MGI:5502477 , PMID:23555679 positive regulation of histone deacetylation ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of MHC class I biosynthetic process IDA 2290270 (MGI:MGI:1314996, PMID:9845074) MGI MGI:MGI:1314996 , PMID:9845074 positive regulation of protein localization to chromosome, telomeric region ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of telomere maintenance ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:1314996, PMID:9845074) MGI MGI:MGI:1314996 , PMID:9845074 proteasome-mediated ubiquitin-dependent protein catabolic process ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein import into nucleus IMP MGI:MGI:2429949 2290270 (MGI:MGI:3054278, PMID:15356634) MGI MGI:MGI:3054278 , PMID:15356634 protein stabilization ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein targeting ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein-containing complex assembly ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of calcium ion transport into cytosol IMP 2290270 (MGI:MGI:4849347, PMID:21030605) UniProtKB MGI:MGI:4849347 , PMID:21030605 regulation of cell adhesion IMP 2290270 (MGI:MGI:5502477, PMID:23555679) CACAO MGI:MGI:5502477 , PMID:23555679 regulation of circadian rhythm IDA 2290270 (MGI:MGI:5314433, PMID:22274616) UniProtKB MGI:MGI:5314433 , PMID:22274616 regulation of double-strand break repair ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of MHC class I biosynthetic process IDA 2290270 (MGI:MGI:1314996, PMID:9845074) MGI MGI:MGI:1314996 , PMID:9845074 regulation of protein phosphorylation IMP 2290270 (MGI:MGI:4849347, PMID:21030605) UniProtKB MGI:MGI:4849347 , PMID:21030605 regulation of transcription, DNA-templated IDA 2290270 (MGI:MGI:1314996, PMID:9845074) MGI MGI:MGI:1314996 , PMID:9845074 regulation of transcription, DNA-templated IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of transcription, DNA-templated ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to cytokine ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to gamma radiation IMP MGI:MGI:2429949 2290270 (MGI:MGI:1306978, PMID:9806545) MGI MGI:MGI:1306978 , PMID:9806545 response to gamma radiation IMP MGI:MGI:104662 2290270 (MGI:MGI:3701394, PMID:11025664) MGI MGI:MGI:3701394 , PMID:11025664 response to hypoxia IMP MGI:MGI:2429949 2290270 (MGI:MGI:3654795, PMID:16915281) MGI MGI:MGI:3654795 , PMID:16915281 response to hypoxia ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to UV IMP MGI:MGI:104662 2290270 (MGI:MGI:3580934, PMID:15626733) MGI MGI:MGI:3580934 , PMID:15626733 retinoic acid receptor signaling pathway IMP MGI:MGI:2429949 2290270 (MGI:MGI:1197798, PMID:9488655) MGI MGI:MGI:1197798 , PMID:9488655 rhythmic process IEA UniProtKB-KW:KW-0090 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 transforming growth factor beta receptor signaling pathway IMP MGI:MGI:2429949 2290270 (MGI:MGI:3054278, PMID:15356634) MGI MGI:MGI:3054278 , PMID:15356634 viral process IEA UniProtKB-KW:KW-0945 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Cellular Component cytoplasm ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoplasm IBA PANTHER:PTN002379290 , UniProtKB:P29590 2290270 (PMID:21873635) GO_Central PMID:21873635 cytosol IDA 2290270 (MGI:MGI:4849347, PMID:21030605) UniProtKB MGI:MGI:4849347 , PMID:21030605 endoplasmic reticulum IEA UniProtKB-KW:KW-0256 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 endosome IEA UniProtKB-KW:KW-0967 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 extrinsic component of endoplasmic reticulum membrane IDA 2290270 (MGI:MGI:4849347, PMID:21030605) UniProtKB MGI:MGI:4849347 , PMID:21030605 heterochromatin colocalizes_with IDA 2290270 (MGI:MGI:5882889, PMID:17081986) CAFA MGI:MGI:5882889 , PMID:17081986 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nuclear chromosome, telomeric region ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nuclear matrix IDA 2290270 (MGI:MGI:3051070, PMID:15252119) MGI MGI:MGI:3051070 , PMID:15252119 nuclear matrix IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 nuclear matrix ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nuclear membrane ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleolus ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleoplasm ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IDA 2290270 (MGI:MGI:1891512 more ... UniProtKB MGI:MGI:1891512 more ... nucleus ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 PML body ISO UniProtKB:P29590 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 PML body IBA MGI:MGI:104662 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 PML body IMP 2290270 (MGI:MGI:3717519, PMID:10779416) UniProtKB MGI:MGI:3717519 , PMID:10779416 PML body IDA 2290270 (MGI:MGI:3616374 more ... MGI MGI:MGI:3616374 more ... Molecular Function cobalt ion binding ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 DNA binding IEA UniProtKB-KW:KW-0238 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI UniProtKB:Q16236 2290270 (MGI:MGI:6212886, PMID:28777872) IntAct MGI:MGI:6212886 , PMID:28777872 protein binding IPI UniProtKB:P70227 2290270 (MGI:MGI:4849347, PMID:21030605) UniProtKB MGI:MGI:4849347 , PMID:21030605 protein binding IPI UniProtKB:O54943 2290270 (MGI:MGI:5314433, PMID:22274616) UniProtKB MGI:MGI:5314433 , PMID:22274616 protein binding IPI UniProtKB:Q60979 2290270 (MGI:MGI:4397769, PMID:19745809) IntAct MGI:MGI:4397769 , PMID:19745809 protein binding IPI UniProtKB:Q14DJ8 2290270 (MGI:MGI:5315336, PMID:21057547) IntAct MGI:MGI:5315336 , PMID:21057547 protein binding IPI UniProtKB:Q505F1 2290270 (MGI:MGI:5919259, PMID:17187077) IntAct MGI:MGI:5919259 , PMID:17187077 protein binding IPI UniProtKB:Q8UN00 2290270 (MGI:MGI:5543889, PMID:22685230) IntAct MGI:MGI:5543889 , PMID:22685230 protein binding IPI RefSeq:NP_110467 2290270 (MGI:MGI:2449749 more ... MGI MGI:MGI:2449749 more ... protein binding IPI UniProtKB:Q9JLN9 2290270 (MGI:MGI:3654795, PMID:16915281) MGI MGI:MGI:3654795 , PMID:16915281 protein binding IPI UniProtKB:P25446 2290270 (MGI:MGI:5320263, PMID:21803845) IntAct MGI:MGI:5320263 , PMID:21803845 protein binding IPI RefSeq:NP_899123 2290270 (MGI:MGI:3054278, PMID:15356634) MGI MGI:MGI:3054278 , PMID:15356634 protein heterodimerization activity ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein homodimerization activity ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 SMAD binding IDA 2290270 (MGI:MGI:3054278, PMID:15356634) MGI MGI:MGI:3054278 , PMID:15356634 SMAD binding IBA MGI:MGI:104662 , PANTHER:PTN002379290 2290270 (PMID:21873635) GO_Central PMID:21873635 SUMO binding ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 SUMO binding IBA PANTHER:PTN002379290 , UniProtKB:P29590 2290270 (PMID:21873635) GO_Central PMID:21873635 transcription coactivator activity ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transcription coactivator activity IBA PANTHER:PTN002379290 , UniProtKB:P29590 2290270 (PMID:21873635) GO_Central PMID:21873635 transcription coactivator activity TAS 2290270 (MGI:MGI:3580934, PMID:15626733) UniProtKB MGI:MGI:3580934 , PMID:15626733 ubiquitin protein ligase binding ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 zinc ion binding ISO UniProtKB:P29590 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Gene-Chemical Interaction Annotations
