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Gene: Zic3 (zinc finger protein of the cerebellum 3) Mus musculus
Symbol: Zic3
Name: zinc finger protein of the cerebellum 3
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; determination of left/right symmetry; and positive regulation of transcription by RNA polymerase II. Localizes to the cytoplasm and nucleus. Used to study Goldenhar syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in situs inversus and visceral heterotaxy. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; embryo mesoderm; and primitive streak. Orthologous to human ZIC3 (Zic family member 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Bn; Ka; Zic family member 3 (odd-paired homolog, Drosophila); zinc finger protein ZIC 3
Homo sapiens (human) : ZIC3 (Zic family member 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Zic3 (Zic family member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zic3 (Zic family member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ZIC3 (Zic family member 3)
Canis lupus familiaris (dog) : ZIC3 (Zic family member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zic3 (Zic family member 3)
Sus scrofa (pig) : ZIC3 (Zic family member 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38X58,030,628 - 58,036,630 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X55,283,805 - 55,289,807 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X54,377,427 - 54,382,686 (+)NCBImm8
CeleraX44,504,773 - 44,510,775 (+)NCBICelera
Cytogenetic MapX A6NCBI
cM MapX32.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Zic3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557273
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.