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Gene: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) Mus musculus
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Symbol: Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; isocitrate metabolic process; and negative regulation of gliogenesis. Localizes to cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; and intrahepatic cholangiocarcinoma. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (N(omega)-L-arginino)succinic acid; (R)-carnitine; (R)-pantothenic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E430004F23; ICD-M; IDH; Idh-2; IDP; IDPm; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; NADP+-specific isocitrate dehydrogenase; oxalosuccinate decarboxylase
Orthologs:
Homo sapiens (human) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Canis lupus familiaris (dog) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Sus scrofa (pig) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Chlorocebus sabaeus (African green monkey) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Heterocephalus glaber (naked mole-rat) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBImm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Idh2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557355
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.