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Gene: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) Mus musculus
Symbol: Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; isocitrate metabolic process; and negative regulation of gliogenesis. Localizes to cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; and intrahepatic cholangiocarcinoma. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (N(omega)-L-arginino)succinic acid; (R)-carnitine; (R)-pantothenic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E430004F23; ICD-M; IDH; Idh-2; IDP; IDPm; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; NADP+-specific isocitrate dehydrogenase; oxalosuccinate decarboxylase
Homo sapiens (human) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Canis lupus familiaris (dog) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Sus scrofa (pig) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Chlorocebus sabaeus (African green monkey) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Heterocephalus glaber (naked mole-rat) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBImm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Idh2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557355
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.