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Gene: Msh3 (mutS homolog 3) Mus musculus
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Symbol: Msh3
Name: mutS homolog 3
Description: Exhibits centromeric DNA binding activity and damaged DNA binding activity. Predicted to contribute to dinucleotide repeat insertion binding activity; single guanine insertion binding activity; and single-stranded DNA binding activity. Involved in mismatch repair and somatic recombination of immunoglobulin gene segments. Predicted to localize to MutSbeta complex. Is expressed in early conceptus; oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; and familial adenomatous polyposis 4. Orthologous to human MSH3 (mutS homolog 3); PARTICIPATES IN mismatch repair pathway; colorectal cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D13Em1; DNA mismatch repair protein Msh3; protein repair-1; protein repair-3; REP-1; Rep-3; Rep3
Orthologs:
Homo sapiens (human) : MSH3 (mutS homolog 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Msh3 (mutS homolog 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh3 (mutS homolog 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH3 (mutS homolog 3)
Canis lupus familiaris (dog) : MSH3 (mutS homolog 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh3 (mutS homolog 3)
Sus scrofa (pig) : MSH3 (mutS homolog 3)
Chlorocebus sabaeus (African green monkey) : MSH3 (mutS homolog 3)
Heterocephalus glaber (naked mole-rat) : Msh3 (mutS homolog 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1392,211,872 - 92,355,003 (-)EnsemblGRCm38mm10GRCm38
GRCm381392,211,878 - 92,355,004 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371392,981,836 - 93,124,958 (-)NCBIGRCm37mm9NCBIm37
MGSCv361393,312,634 - 93,455,756 (-)NCBImm8
Celera1395,828,509 - 95,961,232 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Msh3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557363
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.