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Gene: Rrm2b (ribonucleotide reductase M2 B (TP53 inducible)) Mus musculus
Symbol: Rrm2b
Name: ribonucleotide reductase M2 B (TP53 inducible)
Description: Exhibits ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in several processes, including mitochondrial DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to localize to cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: p53; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B
Related Pseudogenes: Gm8616  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1537,923,952 - 37,961,318 (-)EnsemblGRCm38mm10GRCm38
GRCm381537,923,952 - 37,961,119 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371537,853,707 - 37,890,810 (-)NCBIGRCm37mm9NCBIm37
MGSCv361537,868,541 - 37,905,644 (-)NCBImm8
Celera1538,542,769 - 38,579,866 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rrm2b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557502
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.