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Gene: Tlx1 (T cell leukemia, homeobox 1) Mus musculus
Symbol: Tlx1
Name: T cell leukemia, homeobox 1
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and spleen development. Predicted to localize to nucleus. Is expressed in several structures, including alimentary system; branchial arch; ear; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in adult T-cell leukemia. Orthologous to human TLX1 (T cell leukemia homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein Hox-11; homeobox TLX-1; Hox-11; Hox11; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; Tlx-1
Homo sapiens (human) : TLX1 (T cell leukemia homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tlx1 (T-cell leukemia, homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlx1 (T cell leukemia homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TLX1 (T cell leukemia homeobox 1)
Canis lupus familiaris (dog) : TLX1 (T cell leukemia homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlx1 (T cell leukemia homeobox 1)
Sus scrofa (pig) : TLX1 (T cell leukemia homeobox 1)
Chlorocebus sabaeus (African green monkey) : TLX1 (T cell leukemia homeobox 1)
Heterocephalus glaber (naked mole-rat) : Tlx1 (T cell leukemia homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1945,150,680 - 45,156,943 (+)EnsemblGRCm38mm10GRCm38
GRCm381945,150,092 - 45,156,943 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371945,225,205 - 45,231,433 (+)NCBIGRCm37mm9NCBIm37
MGSCv361945,204,026 - 45,210,254 (+)NCBImm8
Celera1945,915,431 - 45,921,662 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Tlx1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557716
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.