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Gene: Lrrk2 (leucine-rich repeat kinase 2) Mus musculus
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Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
Description: Exhibits several functions, including Rho GTPase binding activity; beta-catenin destruction complex binding activity; and identical protein binding activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Localizes to several cellular components, including the Wnt signalosome; cytoplasmic vesicle; and mitochondrion. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; and cancer. Is expressed in several structures, including gut; immune system; liver; lung; and musculature. Orthologous to human LRRK2 (leucine rich repeat kinase 2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1,1-dichloroethene; 4-hydroxyphenyl retinamide; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4921513O20Rik; 9330188B09Rik; AW561911; cI-46; D630001M17Rik; Gm927; leucine-rich repeat serine/threonine-protein kinase 2
Orthologs:
Homo sapiens (human) : LRRK2 (leucine rich repeat kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrrk2 (leucine-rich repeat kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrk2 (leucine rich repeat kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRK2 (leucine rich repeat kinase 2)
Canis lupus familiaris (dog) : LRRK2 (leucine rich repeat kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrk2 (leucine rich repeat kinase 2)
Sus scrofa (pig) : LRRK2 (leucine rich repeat kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381591,672,791 - 91,816,124 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371591,503,655 - 91,646,555 (+)NCBIGRCm37mm9NCBIm37
MGSCv361591,501,048 - 91,643,302 (+)NCBImm8
Celera1593,785,543 - 93,930,186 (+)NCBICelera
Cytogenetic Map15 E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lrrk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557751
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.