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Gene: Lrrk2 (leucine-rich repeat kinase 2) Mus musculus
Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
CRRD ID: 1557751
Description: Exhibits several functions, including Rho GTPase binding activity; beta-catenin destruction complex binding activity; and identical protein binding activity. Involved in several processes, including protein localization to organelle; regulation of cellular protein metabolic process; and regulation of signal transduction. Localizes to several cellular components, including Wnt signalosome; cytoplasmic vesicle; and mitochondrion. Is expressed in several structures, including gut; immune system; liver; lung; and musculature. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4921513O20Rik; 9330188B09Rik; AW561911; cI-4; cI-46; D630001M17Rik; Gm927; leucine-rich repeat serine/threonine-protein kinase 2
Homo sapiens (human) : LRRK2 (leucine rich repeat kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrrk2 (leucine-rich repeat kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrk2 (leucine rich repeat kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRK2 (leucine rich repeat kinase 2)
Canis lupus familiaris (dog) : LRRK2 (leucine rich repeat kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrk2 (leucine rich repeat kinase 2)
Sus scrofa (pig) : LRRK2 (leucine rich repeat kinase 2)
Chlorocebus sabaeus (African green monkey) : LRRK2 (leucine rich repeat kinase 2)
Heterocephalus glaber (naked mole-rat) : Lrrk2 (leucine rich repeat kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391591,556,994 - 91,700,327 (+)NCBI
GRCm381591,672,791 - 91,816,124 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1591,673,175 - 91,816,120 (+)EnsemblGRCm38mm10GRCm38
MGSCv371591,503,655 - 91,646,555 (+)NCBIGRCm37mm9NCBIm37
MGSCv361591,501,048 - 91,643,302 (+)NCBImm8
Celera1593,785,543 - 93,930,186 (+)NCBICelera
Cytogenetic Map15E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lrrk2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557751
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.