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Gene: Ddx3x (DEAD box helicase 3, X-linked) Mus musculus
Symbol: Ddx3x
Name: DEAD box helicase 3, X-linked
CRRD ID: 1557808
Description: Exhibits primary miRNA binding activity. Involved in positive regulation of NLRP3 inflammasome complex assembly; primary miRNA processing; and stress granule assembly. Localizes to NLRP3 inflammasome complex and cytoplasmic stress granule. Predicted to colocalize with cytosolic small ribosomal subunit and eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-dependent RNA helicase DDX3X; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas; D1Pas1-related sequence 2; D1Pas1-rs2; Ddx3; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD box protein 3, X-chromosomal; DEAD box RNA helicase DEAD3; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; embryonic RNA helicase; fibroblast growth factor inducible 14; Fin; Fin14; mDEAD3
Homo sapiens (human) : DDX3X (DEAD-box helicase 3 X-linked)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ddx3x (DEAD-box helicase 3, X-linked)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx3x (DEAD-box helicase 3 X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX3X (DEAD-box helicase 3 X-linked)
Canis lupus familiaris (dog) : DDX3X (DEAD-box helicase 3 X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx3x (DEAD-box helicase 3 X-linked)
Sus scrofa (pig) : DDX3X (DEAD-box helicase 3 X-linked)
Chlorocebus sabaeus (African green monkey) : DDX3X (DEAD-box helicase 3 X-linked)
Heterocephalus glaber (naked mole-rat) : Ddx3x (DEAD-box helicase 3 X-linked)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X13,147,261 - 13,160,222 (+)NCBI
GRCm38X13,280,496 - 13,293,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX13,280,970 - 13,294,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X12,858,148 - 12,871,109 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X12,437,997 - 12,449,573 (+)NCBImm8
CeleraX10,940,806 - 10,968,272 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Ddx3x
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557808
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.