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Gene: Foxp3 (forkhead box P3) Mus musculus
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Symbol: Foxp3
Name: forkhead box P3
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and transcription corepressor activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of T cell tolerance induction; and regulation of lymphocyte activation. Localizes to the cytoplasm and nucleus. Used to study Wiskott-Aldrich syndrome and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. Human ortholog(s) of this gene implicated in immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome and type 1 diabetes mellitus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human FOXP3 (forkhead box P3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: forkhead box protein P3; JM2; scurfin; scurfy; sf
Orthologs:
Homo sapiens (human) : FOXP3 (forkhead box P3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Foxp3 (forkhead box P3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxp3 (forkhead box P3)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXP3 (forkhead box P3)
Canis lupus familiaris (dog) : FOXP3 (forkhead box P3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxp3 (forkhead box P3)
Sus scrofa (pig) : FOXP3 (forkhead box P3)
Chlorocebus sabaeus (African green monkey) : FOXP3 (forkhead box P3)
Heterocephalus glaber (naked mole-rat) : Foxp3 (forkhead box P3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 EnsemblX7,573,644 - 7,595,245 (+)Ensembl
GRCm38X7,579,676 - 7,595,243 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X7,156,819 - 7,172,360 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X6,736,652 - 6,752,193 (+)NCBImm8
CeleraX3,876,528 - 3,892,094 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Foxp3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557838
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.