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Gene: Foxp3 (forkhead box P3) Mus musculus
Symbol: Foxp3
Name: forkhead box P3
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and transcription corepressor activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of T cell tolerance induction; and regulation of lymphocyte activation. Localizes to the cytoplasm and nucleus. Used to study Wiskott-Aldrich syndrome and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. Human ortholog(s) of this gene implicated in immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome and type 1 diabetes mellitus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human FOXP3 (forkhead box P3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: forkhead box protein P3; JM2; scurfin; scurfy; sf
Homo sapiens (human) : FOXP3 (forkhead box P3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Foxp3 (forkhead box P3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxp3 (forkhead box P3)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXP3 (forkhead box P3)
Canis lupus familiaris (dog) : FOXP3 (forkhead box P3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxp3 (forkhead box P3)
Sus scrofa (pig) : FOXP3 (forkhead box P3)
Chlorocebus sabaeus (African green monkey) : FOXP3 (forkhead box P3)
Heterocephalus glaber (naked mole-rat) : Foxp3 (forkhead box P3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX7,573,644 - 7,595,245 (+)Ensembl
GRCm38X7,579,676 - 7,595,243 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X7,156,819 - 7,172,360 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X6,736,652 - 6,752,193 (+)NCBImm8
CeleraX3,876,528 - 3,892,094 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Foxp3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557838
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.