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Gene: Ryr2 (ryanodine receptor 2, cardiac) Mus musculus
Symbol: Ryr2
Name: ryanodine receptor 2, cardiac
Description: Exhibits several functions, including calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to organonitrogen compound; heart morphogenesis; and regulation of heart contraction. Localizes to the Z disc; calcium channel complex; and endoplasmic reticulum. Used to study arrhythmogenic right ventricular dysplasia 2 and catecholaminergic polymorphic ventricular tachycardia 1. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human RYR2 (ryanodine receptor 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 4,4'-sulfonyldiphenol; baclofen.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9330127I20Rik; calcium release channel; cardiac muscle ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; ryanodine receptor 2; ryanodine receptor type 2; RYR-2; type 2 ryanodine receptor
Homo sapiens (human) : RYR2 (ryanodine receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ryr2 (ryanodine receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ryr2 (ryanodine receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RYR2 (ryanodine receptor 2)
Canis lupus familiaris (dog) : RYR2 (ryanodine receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ryr2 (ryanodine receptor 2)
Sus scrofa (pig) : RYR2 (ryanodine receptor 2)
Chlorocebus sabaeus (African green monkey) : RYR2 (ryanodine receptor 2)
Heterocephalus glaber (naked mole-rat) : Ryr2 (ryanodine receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1311,553,102 - 12,106,945 (-)Ensembl
GRCm381311,553,099 - 12,106,945 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371311,645,370 - 12,199,212 (-)NCBIGRCm37mm9NCBIm37
MGSCv361311,608,677 - 12,160,499 (-)NCBImm8
Celera1311,467,020 - 12,025,871 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences