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Gene: Ifih1 (interferon induced with helicase C domain 1) Mus musculus
Symbol: Ifih1
Name: interferon induced with helicase C domain 1
Description: Predicted to have several functions, including RNA binding activity; identical protein binding activity; and zinc ion binding activity. Involved in innate immune response and response to virus. Predicted to localize to the cytoplasm and nucleus. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human IFIH1 (interferon induced with helicase C domain 1); PARTICIPATES IN influenza A pathway; measles pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9130009C22Rik; Helicard; helicase with 2 CARD domains; Hlcd; interferon induced with helicase C domain protein 1; interferon-induced helicase C domain-containing protein 1; MDA5; melanoma differentiation associated protein-5; melanoma differentiation-associated protein 5; MGC90959; RIG-I-like receptor 2; RLR-2
Homo sapiens (human) : IFIH1 (interferon induced with helicase C domain 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ifih1 (interferon induced with helicase C domain 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ifih1 (interferon induced with helicase C domain 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IFIH1 (interferon induced with helicase C domain 1)
Canis lupus familiaris (dog) : IFIH1 (interferon induced with helicase C domain 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ifih1 (interferon induced with helicase C domain 1)
Sus scrofa (pig) : IFIH1 (interferon induced with helicase C domain 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl262,595,798 - 62,646,255 (-)Ensembl
GRCm38262,595,618 - 62,646,255 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37262,433,850 - 62,484,312 (-)NCBIGRCm37mm9NCBIm37
MGSCv36262,398,289 - 62,451,864 (-)NCBImm8
Celera264,286,036 - 64,336,570 (-)NCBICelera
Cytogenetic Map2 C1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ifih1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557966
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.