Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Iqsec3 (IQ motif and Sec7 domain 3) Mus musculus
Symbol: Iqsec3
Name: IQ motif and Sec7 domain 3
Description: Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including actin cytoskeleton organization; activation of GTPase activity; and regulation of small GTPase mediated signal transduction. Localizes to several cellular components, including the GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization of symmetric synapse. Is expressed in endocrine gland; nervous system; and testis. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AK122446; BRAG3; IQ motif and SEC7 domain-containing protein 3; mKIAA1110; synarfGEF
Homo sapiens (human) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)
Canis lupus familiaris (dog) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)
Sus scrofa (pig) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl6121,372,933 - 121,473,678 (-)Ensembl
GRCm386121,372,927 - 121,473,738 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376121,322,951 - 121,423,696 (-)NCBIGRCm37mm9NCBIm37
MGSCv366121,338,552 - 121,439,297 (-)NCBImm8
Celera6123,209,111 - 123,309,961 (-)NCBICelera
Cytogenetic Map6 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Iqsec3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557973
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.