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Gene: Iqsec3 (IQ motif and Sec7 domain 3) Mus musculus
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Symbol: Iqsec3
Name: IQ motif and Sec7 domain 3
Description: Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including actin cytoskeleton organization; activation of GTPase activity; and regulation of small GTPase mediated signal transduction. Localizes to several cellular components, including the GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization of symmetric synapse. Is expressed in endocrine gland; nervous system; and testis. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AK122446; BRAG3; IQ motif and SEC7 domain-containing protein 3; mKIAA1110; synarfGEF
Orthologs:
Homo sapiens (human) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)
Canis lupus familiaris (dog) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iqsec3 (IQ motif and Sec7 domain ArfGEF 3)
Sus scrofa (pig) : IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl6121,372,933 - 121,473,678 (-)Ensembl
GRCm386121,372,927 - 121,473,738 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376121,322,951 - 121,423,696 (-)NCBIGRCm37mm9NCBIm37
MGSCv366121,338,552 - 121,439,297 (-)NCBImm8
Celera6123,209,111 - 123,309,961 (-)NCBICelera
Cytogenetic Map6 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Iqsec3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557973
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.