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Gene: H2-Ab1 (histocompatibility 2, class II antigen A, beta 1) Mus musculus
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Symbol: H2-Ab1
Name: histocompatibility 2, class II antigen A, beta 1
Description: Exhibits several functions, including peptide antigen binding activity; protein antigen binding activity; and toxic substance binding activity. Involved in several processes, including B cell affinity maturation; antigen processing and presentation of exogenous peptide antigen via MHC class II; and cellular response to interferon-gamma. Localizes to several cellular components, including the MHC class II protein complex; endosome; and external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); bacterial infectious disease (multiple); bone inflammation disease (multiple); bullous skin disease (multiple); and hematologic cancer (multiple). Is expressed in lung and thymus primordium. Orthologous to human HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1) and HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; I-A; I-Abeta; Ia-2; Ia2; IAb; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381734,263,227 - 34,269,418 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,400,172 - 34,406,363 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,871,432 - 33,877,605 (+)NCBImm8
Celera1737,017,337 - 37,030,239 (+)NCBICelera
Cytogenetic Map17 B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on H2-Ab1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1557975
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.