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Gene: Hspg2 (perlecan (heparan sulfate proteoglycan 2)) Mus musculus
Symbol: Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Description: Exhibits protease binding activity. Involved in several processes, including animal organ development; extracellular matrix organization; and skeletal system development. Localizes to basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; early conceptus; genitourinary system; and nervous system. Used to study Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; dextro-looped transposition of the great arteries 1; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2); PARTICIPATES IN Hedgehog signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI852380; basement membrane-specific heparan sulfate proteoglycan core protein; HSPG; Pcn; per; Plc
Homo sapiens (human) : HSPG2 (heparan sulfate proteoglycan 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspg2 (heparan sulfate proteoglycan 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspg2 (heparan sulfate proteoglycan 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPG2 (heparan sulfate proteoglycan 2)
Canis lupus familiaris (dog) : HSPG2 (heparan sulfate proteoglycan 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspg2 (heparan sulfate proteoglycan 2)
Sus scrofa (pig) : HSPG2 (heparan sulfate proteoglycan 2)
Chlorocebus sabaeus (African green monkey) : HSPG2 (heparan sulfate proteoglycan 2)
Heterocephalus glaber (naked mole-rat) : Hspg2 (heparan sulfate proteoglycan 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl4137,468,769 - 137,570,630 (+)EnsemblGRCm38mm10GRCm38
GRCm384137,468,751 - 137,570,630 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374137,024,718 - 137,126,545 (+)NCBIGRCm37mm9NCBIm37
MGSCv364137,024,724 - 137,126,545 (+)NCBImm8
Celera4135,720,332 - 135,778,896 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hspg2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558001
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.