Symbol:
Rfk
Name:
riboflavin kinase
Description:
Predicted to have riboflavin kinase activity. Involved in positive regulation of NAD(P)H oxidase activity and reactive oxygen species metabolic process. Localizes to the mitochondrion. Is expressed in several structures, including alimentary system; facial bone primordium; heart; respiratory system; and urinary system. Orthologous to human RFK (riboflavin kinase); PARTICIPATES IN riboflavin metabolic pathway; INTERACTS WITH 3,3',4,4'-tetrachlorobiphenyl; 4,4'-diaminodiphenylmethane; Aroclor 1254.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
0610038L10Rik; AF031381; ATP:riboflavin 5'-phosphotransferase; flavokinase; KOI-4
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
RFK (riboflavin kinase) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Rfk (riboflavin kinase) RGD
RGD
Chinchilla lanigera (long-tailed chinchilla):
Rfk (riboflavin kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
RFK (riboflavin kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
RFK (riboflavin kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rfk (riboflavin kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
RFK (riboflavin kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
RFK (riboflavin kinase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Rfk (riboflavin kinase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
rfk (riboflavin kinase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
CG2846
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
FMN1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
R10H10.6
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 19 17,394,043 - 17,401,349 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 19 17,468,533 - 17,475,839 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 19 17,461,102 - 17,468,354 (+) NCBI mm8 Celera 19 18,067,535 - 18,074,842 (+) NCBI Celera Cytogenetic Map 19 B NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(-)-demecolcine increases expression ISO RGD:1313443 6480464 Demecolcine results in increased expression of RFK mRNA CTD PMID:23649840 1,1'-azobis(N,N-dimethylformamide) decreases response to substance ISO RGD:1313443 6480464 RFK protein results in decreased susceptibility to Diamide CTD PMID:21308351 2-methoxyethanol increases expression ISO RGD:1549748 6480464 methyl cellosolve results in increased expression of RFK mRNA CTD PMID:21061450 3,3',4,4'-tetrachlorobiphenyl multiple interactions EXP 6480464 3 more ... CTD PMID:19467301 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1313443 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RFK mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RFK mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione increases expression ISO RGD:1549748 6480464 1, 2-dithiol-3-thione results in increased expression of RFK mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of RFK mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1313443 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RFK mRNA CTD PMID:28628672 acrylamide affects expression ISO RGD:1549748 6480464 Acrylamide affects the expression of RFK mRNA CTD PMID:28959563 aflatoxin B1 increases methylation ISO RGD:1313443 6480464 Aflatoxin B1 results in increased methylation of RFK intron CTD PMID:30157460 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of RFK mRNA CTD PMID:23650126 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1313443 6480464 7 more ... CTD PMID:20382639 , PMID:26238291 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of RFK mRNA] CTD PMID:19850644 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of RFK mRNA CTD PMID:19850644 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of RFK mRNA CTD PMID:26063408 bisphenol A increases methylation ISO RGD:1549748 6480464 bisphenol A results in increased methylation of RFK gene CTD PMID:28505145 bisphenol A multiple interactions ISO RGD:1313443 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RFK mRNA CTD PMID:28628672 bisphenol A affects expression ISO RGD:1549748 6480464 bisphenol A affects the expression of RFK mRNA CTD PMID:25181051 calyculin a increases expression EXP 6480464 calyculin A results in increased expression of RFK mRNA CTD PMID:25270620 carbamazepine affects expression ISO RGD:1313443 6480464 Carbamazepine affects the expression of RFK mRNA CTD PMID:25979313 cisplatin decreases response to substance ISO RGD:1313443 6480464 RFK protein results in decreased susceptibility to Cisplatin CTD PMID:21308351 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of RFK mRNA CTD PMID:21151649 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of RFK mRNA CTD PMID:17585979 cyclosporin A increases expression ISO RGD:1313443 6480464 Cyclosporine results in increased expression of RFK mRNA CTD PMID:25562108 dexamethasone multiple interactions ISO RGD:1313443 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RFK mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RFK mRNA CTD PMID:28628672 diazinon increases methylation ISO RGD:1313443 6480464 Diazinon results in increased methylation of RFK gene CTD PMID:22964155 dioxygen multiple interactions EXP 6480464 Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of RFK mRNA] CTD PMID:22629407 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of RFK mRNA CTD PMID:22629407 dorsomorphin multiple interactions ISO RGD:1313443 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1313443 6480464 Doxorubicin results in decreased expression of RFK mRNA CTD PMID:29803840 ethanol affects expression EXP 6480464 Ethanol affects the expression of RFK mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:1313443 6480464 Ethyl Methanesulfonate results in increased expression of RFK mRNA CTD PMID:23649840 FAD increases abundance ISO RGD:1313443 6480464 RFK protein results in increased abundance of Flavin-Adenine Dinucleotide CTD PMID:21308351 flutamide decreases expression ISO RGD:1549748 6480464 Flutamide results in decreased expression of RFK mRNA CTD PMID:24793618 FMN increases abundance ISO RGD:1313443 6480464 RFK protein results in increased abundance of Flavin Mononucleotide CTD PMID:21308351 formaldehyde increases expression ISO RGD:1313443 6480464 Formaldehyde results in increased expression of RFK mRNA CTD PMID:23649840 glutathione increases abundance ISO RGD:1313443 6480464 RFK protein results in increased abundance of Glutathione CTD PMID:21308351 gold atom decreases expression ISO RGD:1313443 6480464 Gold results in decreased expression of RFK mRNA CTD PMID:25523186 gold(0) decreases expression ISO RGD:1313443 6480464 Gold results in decreased expression of RFK mRNA CTD PMID:25523186 hydrogen peroxide decreases response to substance ISO RGD:1313443 6480464 RFK protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:21308351 hydrogen peroxide multiple interactions ISO RGD:1313443 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFK protein CTD PMID:18951874 indometacin multiple interactions ISO RGD:1313443 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RFK mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RFK mRNA CTD PMID:28628672 isotretinoin decreases expression ISO RGD:1313443 6480464 Isotretinoin results in decreased expression of RFK mRNA CTD PMID:20436886 lead(0) affects expression ISO RGD:1313443 6480464 Lead affects the expression of RFK mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1313443 6480464 Lead affects the expression of RFK mRNA CTD PMID:28903495 manganese(II) chloride decreases expression ISO RGD:1549748 6480464 manganese chloride results in decreased expression of RFK mRNA CTD PMID:28801915 methyl methanesulfonate increases expression ISO RGD:1313443 6480464 Methyl Methanesulfonate results in increased expression of RFK mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:1313443 6480464 methylmercuric chloride results in increased expression of RFK mRNA CTD PMID:28001369 nefazodone increases expression ISO RGD:1549748 6480464 nefazodone results in increased expression of RFK mRNA CTD PMID:24136188 paracetamol decreases expression ISO RGD:1313443 6480464 Acetaminophen results in decreased expression of RFK mRNA CTD PMID:22230336 paracetamol increases expression ISO RGD:1313443 6480464 Acetaminophen results in increased expression of RFK mRNA CTD PMID:29067470 phenylmercury acetate increases expression ISO RGD:1313443 6480464 Phenylmercuric Acetate results in increased expression of RFK mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1313443 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFK mRNA CTD PMID:27188386 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of RFK mRNA CTD PMID:17426115 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of RFK mRNA CTD PMID:18301758 , PMID:23811191 raloxifene affects expression ISO RGD:1313443 6480464 Raloxifene Hydrochloride affects the expression of RFK mRNA CTD PMID:14699072 raloxifene multiple interactions ISO RGD:1313443 6480464 [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RFK mRNA CTD PMID:19059307 SB 431542 multiple interactions ISO RGD:1313443 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos increases expression ISO RGD:1313443 6480464 Asbestos, Serpentine results in increased expression of RFK mRNA CTD PMID:21148743 tamoxifen affects expression ISO RGD:1313443 6480464 Tamoxifen affects the expression of RFK mRNA CTD PMID:14699072 tamoxifen multiple interactions ISO RGD:1313443 6480464 [Tamoxifen co-treated with ESR2 protein] results in increased expression of RFK mRNA CTD PMID:19059307 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of RFK mRNA CTD PMID:21669218 theophylline multiple interactions ISO RGD:1313443 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFK protein CTD PMID:18951874 trichostatin A decreases expression ISO RGD:1313443 6480464 trichostatin A results in decreased expression of RFK mRNA CTD PMID:26272509 trichostatin A multiple interactions ISO RGD:1313443 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFK mRNA CTD PMID:27188386 tunicamycin decreases expression EXP 6480464 Tunicamycin results in decreased expression of RFK mRNA CTD PMID:17127020 valproic acid increases methylation ISO RGD:1313443 6480464 Valproic Acid results in increased methylation of RFK gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1313443 6480464 Valproic Acid results in increased expression of RFK mRNA CTD PMID:23179753 more ... valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of RFK mRNA CTD PMID:17292431 , PMID:17963808 valproic acid affects expression ISO RGD:1313443 6480464 Valproic Acid affects the expression of RFK mRNA CTD PMID:25979313 vinclozolin increases expression ISO RGD:1549748 6480464 vinclozolin results in increased expression of RFK mRNA CTD PMID:23034163 
Gene-Chemical Interaction Annotations
