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Gene: Lrsam1 (leucine rich repeat and sterile alpha motif containing 1) Mus musculus
Symbol: Lrsam1
Name: leucine rich repeat and sterile alpha motif containing 1
Description: Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of macroautophagy; protein ubiquitination; and ubiquitin-dependent endocytosis. Predicted to localize to the cytosol and membrane. Used to study Charcot-Marie-Tooth disease axonal type 2P. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2P. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and olfactory epithelium. Orthologous to human LRSAM1 (leucine rich repeat and sterile alpha motif containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase LRSAM1; leucine-rich repeat and sterile alpha motif-containing protein 1; MGC56830; RING-type E3 ubiquitin transferase LRSAM1; tsg101-associated ligase
Related Pseudogenes: 4930555K19Rik  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38232,925,215 - 32,961,668 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37232,780,740 - 32,816,771 (-)NCBIGRCm37mm9NCBIm37
MGSCv36232,747,229 - 32,783,260 (-)NCBImm8
Celera232,632,197 - 32,668,237 (-)NCBICelera
Cytogenetic Map2 BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lrsam1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558134
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.