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Gene: H2-Eb1 (histocompatibility 2, class II antigen E beta) Mus musculus
Symbol: H2-Eb1
Name: histocompatibility 2, class II antigen E beta
CRRD ID: 1558147
Description: Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and response to interferon-gamma. Predicted to localize to late endosome membrane and lysosomal membrane. Is expressed in lung. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5); PARTICIPATES IN interleukin-12 signaling pathway; allograft rejection pathway; antigen processing and presentation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell surface glycoprotein; Eb; H-2 class II histocompatibility antigen, I-E beta chain; H-2Eb; H2-Eb_p; H2Eb; histocompatibility 2, class II antigen E beta, promoter 1; I; I-E beta MHC class II; Ia; Ia-4; Ia4; major histocompatibility complex H-2E beta chain; MGC163794; MGC163796; MHC class II antigen beta chain; MHC class II IE-b; MHC H2-IE-beta cell surface glycoprotein
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,524,841 - 34,535,648 (+)NCBI
GRCm381734,305,867 - 34,316,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,305,867 - 34,316,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,442,812 - 34,453,619 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,913,637 - 33,923,895 (+)NCBImm8
Celera1737,067,715 - 37,078,914 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-Eb1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558147
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.