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Gene: Kdm5c (lysine (K)-specific demethylase 5C) Mus musculus
Symbol: Kdm5c
Name: lysine (K)-specific demethylase 5C
Description: Predicted to have several functions, including RNA polymerase II transcription factor binding activity; histone demethylase activity (H3-trimethyl-K4 specific); and zinc ion binding activity. Involved in histone H3-K4 demethylation and negative regulation of transcription, DNA-templated. Localizes to nucleus. Is expressed in several structures, including brain; early conceptus; gonad; limb; and metanephros. Used to study syndromic X-linked intellectual disability Claes-Jensen type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to human KDM5C (lysine demethylase 5C); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; INTERACTS WITH 4-hydroxyphenyl retinamide; aflatoxin B1; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: [histone H3]-trimethyl-L-lysine(4) demethylase 5C; D930009K15Rik; histone demethylase JARID1C; Jarid1c; jumonji, AT rich interactive domain 1C (Rbp2 like); jumonji/ARID domain-containing protein 1C; lysine-specific demethylase 5C; mKIAA0234; RIKEN cDNA D930009K15 gene; selected mouse cDNA on the X; Smcx
Homo sapiens (human) : KDM5C (lysine demethylase 5C)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kdm5c (lysine demethylase 5C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm5c (lysine demethylase 5C)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM5C (lysine demethylase 5C)
Canis lupus familiaris (dog) : KDM5C (lysine demethylase 5C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm5c (lysine demethylase 5C)
Sus scrofa (pig) : KDM5C (lysine demethylase 5C)
Chlorocebus sabaeus (African green monkey) : KDM5C (lysine demethylase 5C)
Heterocephalus glaber (naked mole-rat) : Kdm5c (lysine demethylase 5C)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX152,233,020 - 152,274,535 (+)EnsemblGRCm38mm10GRCm38
GRCm38X152,233,198 - 152,279,102 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X148,667,773 - 148,708,897 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X147,573,988 - 147,614,512 (+)NCBImm8
MGSCv36X129,241,757 - 129,282,281 (+)NCBImm8
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kdm5c
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558152
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.