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Gene: Irf3 (interferon regulatory factor 3) Mus musculus
Symbol: Irf3
Name: interferon regulatory factor 3
CRRD ID: 1558245
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; regulation of defense response; and regulation of type I interferon production. Localizes to cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; and telencephalon. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-phenylprop-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C920001K05Rik; IRF; IRF-3; MGC91046
Homo sapiens (human) : IRF3 (interferon regulatory factor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irf3 (interferon regulatory factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf3 (interferon regulatory factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF3 (interferon regulatory factor 3)
Canis lupus familiaris (dog) : IRF3 (interferon regulatory factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf3 (interferon regulatory factor 3)
Sus scrofa (pig) : IRF3 (interferon regulatory factor 3)
Chlorocebus sabaeus (African green monkey) : IRF3 (interferon regulatory factor 3)
Heterocephalus glaber (naked mole-rat) : Irf3 (interferon regulatory factor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39744,647,072 - 44,652,272 (+)NCBI
GRCm38744,997,648 - 45,002,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,997,648 - 45,002,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,253,030 - 52,258,218 (+)NCBIGRCm37mm9NCBIm37
MGSCv36744,865,702 - 44,870,890 (+)NCBImm8
Celera740,449,220 - 40,454,417 (+)NCBICelera
Cytogenetic Map7B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Irf3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558245
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.