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Gene: H2-T23 (histocompatibility 2, T region locus 23) Mus musculus
Symbol: H2-T23
Name: histocompatibility 2, T region locus 23
CRRD ID: 1558332
Description: Predicted to have beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; inner ear development; and positive regulation of T cell mediated cytotoxicity. Predicted to localize to MHC protein complex; external side of plasma membrane; and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in asthma and hepatitis C. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrobenzenesulfonic acid.
Type: protein-coding
Also known as: 37b; 37c; H-2 class I histocompatibility antigen, D-37 alpha chain; H-2T23; H2-K1; H2-Qa1; MGC117681; MHC class I antigen Qa1; MHC class II antigen K; MHC classIb Qa1; Qa; Qa-; Qa-1; Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391736,340,869 - 36,343,593 (-)NCBI
GRCm381736,029,977 - 36,032,701 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1736,029,773 - 36,032,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv371736,166,922 - 36,169,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv361735,638,030 - 35,640,754 (-)NCBImm8
Celera1739,547,532 - 39,600,702 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-T23
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558332
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.