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Gene: Pkd2 (polycystin 2, transient receptor potential cation channel) Mus musculus
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Symbol: Pkd2
Name: polycystin 2, transient receptor potential cation channel
Description: Exhibits several functions, including ATPase binding activity; cation channel activity; and identical protein binding activity. Involved in several processes, including animal organ development; detection of nodal flow; and inorganic cation transmembrane transport. Localizes to several cellular components, including the basal cortex; microtubule cytoskeleton; and polycystin complex. Colocalizes with the cell-cell junction. Used to study autosomal dominant polycystic kidney disease; polycystic kidney disease 1; and polycystic kidney disease 2. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C030034P18Rik; PC2; polycystic kidney disease 2; polycystic kidney disease 2 protein homolog; polycystin 2; polycystin-2; transient receptor potential cation channel subfamily P member 2; TRPP2
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5104,459,450 - 104,505,819 (+)EnsemblGRCm38mm10GRCm38
GRCm385104,453,982 - 104,505,819 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375104,888,476 - 104,934,838 (+)NCBIGRCm37mm9NCBIm37
MGSCv365104,699,856 - 104,746,118 (+)NCBImm8
Celera5101,769,092 - 101,817,838 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Pkd2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558338
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.