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Gene: Flna (filamin, alpha) Mus musculus
Symbol: Flna
Name: filamin, alpha
CRRD ID: 1558370
Description: Exhibits potassium channel regulator activity and protein kinase C binding activity. Involved in several processes, including circulatory system development; regulation of ion transmembrane transport; and regulation of neuron projection development. Localizes to several cellular components, including Z disc; axonal growth cone; and trans-Golgi network. Predicted to colocalize with actin filament. Is expressed in several structures, including brain; great vessel of heart; gut; heart and pericardium; and proepicardium. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in X-linked recessive disease (multiple); bone development disease (multiple); heart valve disease (multiple); and periventricular nodular heterotopia. Orthologous to human FLNA (filamin A); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; Rho/Rac/Cdc42 mediated signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ABP-2; ABP-280; actin-binding protein 280; alpha-filamin; Di; dilated pupils 2; Dilp2; endothelial actin-binding protein; F730004A14Rik; fila; filamin A; filamin-1; filamin-A; Fl; FLN-A; Fln1; GENA 379; non-muscle filamin
Homo sapiens (human) : FLNA (filamin A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flna (filamin A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flna (filamin A)
Pan paniscus (bonobo/pygmy chimpanzee) : FLNA (filamin A)
Canis lupus familiaris (dog) : FLNA (filamin A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flna (filamin A)
Sus scrofa (pig) : FLNA (filamin A)
Chlorocebus sabaeus (African green monkey) : FLNA (filamin A)
Heterocephalus glaber (naked mole-rat) : Flna (filamin A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX74,223,461 - 74,249,820 (-)EnsemblGRCm38mm10GRCm38
GRCm38X74,223,461 - 74,249,854 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X71,468,800 - 71,491,873 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X71,468,800 - 71,491,873 (-)NCBImm8
CeleraX65,477,570 - 65,500,684 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Flna
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558370
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.